-transparent.png){kind=logo}
Predictors of long-term disability accrual in relapse-onset multiple sclerosis. 2016
Vilija G Jokubaitis, and
Tim Spelman, and
Tomas Kalincik, and
Johannes Lorscheider, and
Eva Havrdova, and
Dana Horakova, and
Pierre Duquette, and
Marc Girard, and
Alexandre Prat, and
Guillermo Izquierdo, and
Pierre Grammond, and
Vincent Van Pesch, and
Eugenio Pucci, and
François Grand'Maison, and
Raymond Hupperts, and
Franco Granella, and
Patrizia Sola, and
Roberto Bergamaschi, and
Gerardo Iuliano, and
Daniele Spitaleri, and
Cavit Boz, and
Suzanne Hodgkinson, and
Javier Olascoaga, and
Freek Verheul, and
Pamela McCombe, and
Thor Petersen, and
Csilla Rozsa, and
Jeannette Lechner-Scott, and
Maria Laura Saladino, and
Deborah Farina, and
Pietro Iaffaldano, and
Damiano Paolicelli, and
Helmut Butzkueven, and
Alessandra Lugaresi, and
Maria Trojano, and
Department of Medicine and Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.
To identify predictors of 10-year Expanded Disability Status Scale (EDSS) change after treatment initiation in patients with relapse-onset multiple sclerosis. Using data obtained from MSBase, we defined baseline as the date of first injectable therapy initiation. Patients need only have remained on injectable therapy for 1 day and were monitored on any approved disease-modifying therapy, or no therapy thereafter. Median EDSS score changes over a 10-year period were determined. Predictors of EDSS change were then assessed using median quantile regression analysis. Sensitivity analyses were further performed. We identified 2,466 patients followed up for at least 10 years reporting post-baseline disability scores. Patients were treated an average 83% of their follow-up time. EDSS scores increased by a median 1 point (interquartile range = 0-2) at 10 years post-baseline. Annualized relapse rate was highly predictive of increases in median EDSS over 10 years (coeff = 1.14, p = 1.9 × 10(-22) ). On-therapy relapses carried greater burden than off-therapy relapses. Cumulative treatment exposure was independently associated with lower EDSS at 10 years (coeff = -0.86, p = 1.3 × 10(-9) ). Furthermore, pregnancies were also independently associated with lower EDSS scores over the 10-year observation period (coeff = -0.36, p = 0.009). We provide evidence of long-term treatment benefit in a large registry cohort, and provide evidence of long-term protective effects of pregnancy against disability accrual. We demonstrate that high annualized relapse rate, particularly on-treatment relapse, is an indicator of poor prognosis. Ann Neurol 2016;80:89-100.
Related Publications
Vilija G Jokubaitis, and
Tim Spelman, and
Tomas Kalincik, and
Johannes Lorscheider, and
Eva Havrdova, and
Dana Horakova, and
Pierre Duquette, and
Marc Girard, and
Alexandre Prat, and
Guillermo Izquierdo, and
Pierre Grammond, and
Vincent Van Pesch, and
Eugenio Pucci, and
François Grand'Maison, and
Raymond Hupperts, and
Franco Granella, and
Patrizia Sola, and
Roberto Bergamaschi, and
Gerardo Iuliano, and
Daniele Spitaleri, and
Cavit Boz, and
Suzanne Hodgkinson, and
Javier Olascoaga, and
Freek Verheul, and
Pamela McCombe, and
Thor Petersen, and
Csilla Rozsa, and
Jeannette Lechner-Scott, and
Maria Laura Saladino, and
Deborah Farina, and
Pietro Iaffaldano, and
Damiano Paolicelli, and
Helmut Butzkueven, and
Alessandra Lugaresi, and
Maria Trojano, and
August 2019,
Brain : a journal of neurology,
Vilija G Jokubaitis, and
Tim Spelman, and
Tomas Kalincik, and
Johannes Lorscheider, and
Eva Havrdova, and
Dana Horakova, and
Pierre Duquette, and
Marc Girard, and
Alexandre Prat, and
Guillermo Izquierdo, and
Pierre Grammond, and
Vincent Van Pesch, and
Eugenio Pucci, and
François Grand'Maison, and
Raymond Hupperts, and
Franco Granella, and
Patrizia Sola, and
Roberto Bergamaschi, and
Gerardo Iuliano, and
Daniele Spitaleri, and
Cavit Boz, and
Suzanne Hodgkinson, and
Javier Olascoaga, and
Freek Verheul, and
Pamela McCombe, and
Thor Petersen, and
Csilla Rozsa, and
Jeannette Lechner-Scott, and
Maria Laura Saladino, and
Deborah Farina, and
Pietro Iaffaldano, and
Damiano Paolicelli, and
Helmut Butzkueven, and
Alessandra Lugaresi, and
Maria Trojano, and
June 2019,
Neurology,
Vilija G Jokubaitis, and
Tim Spelman, and
Tomas Kalincik, and
Johannes Lorscheider, and
Eva Havrdova, and
Dana Horakova, and
Pierre Duquette, and
Marc Girard, and
Alexandre Prat, and
Guillermo Izquierdo, and
Pierre Grammond, and
Vincent Van Pesch, and
Eugenio Pucci, and
François Grand'Maison, and
Raymond Hupperts, and
Franco Granella, and
Patrizia Sola, and
Roberto Bergamaschi, and
Gerardo Iuliano, and
Daniele Spitaleri, and
Cavit Boz, and
Suzanne Hodgkinson, and
Javier Olascoaga, and
Freek Verheul, and
Pamela McCombe, and
Thor Petersen, and
Csilla Rozsa, and
Jeannette Lechner-Scott, and
Maria Laura Saladino, and
Deborah Farina, and
Pietro Iaffaldano, and
Damiano Paolicelli, and
Helmut Butzkueven, and
Alessandra Lugaresi, and
Maria Trojano, and
June 2018,
Acta neurologica Belgica,
Vilija G Jokubaitis, and
Tim Spelman, and
Tomas Kalincik, and
Johannes Lorscheider, and
Eva Havrdova, and
Dana Horakova, and
Pierre Duquette, and
Marc Girard, and
Alexandre Prat, and
Guillermo Izquierdo, and
Pierre Grammond, and
Vincent Van Pesch, and
Eugenio Pucci, and
François Grand'Maison, and
Raymond Hupperts, and
Franco Granella, and
Patrizia Sola, and
Roberto Bergamaschi, and
Gerardo Iuliano, and
Daniele Spitaleri, and
Cavit Boz, and
Suzanne Hodgkinson, and
Javier Olascoaga, and
Freek Verheul, and
Pamela McCombe, and
Thor Petersen, and
Csilla Rozsa, and
Jeannette Lechner-Scott, and
Maria Laura Saladino, and
Deborah Farina, and
Pietro Iaffaldano, and
Damiano Paolicelli, and
Helmut Butzkueven, and
Alessandra Lugaresi, and
Maria Trojano, and
September 2007,
Archives of neurology,
Vilija G Jokubaitis, and
Tim Spelman, and
Tomas Kalincik, and
Johannes Lorscheider, and
Eva Havrdova, and
Dana Horakova, and
Pierre Duquette, and
Marc Girard, and
Alexandre Prat, and
Guillermo Izquierdo, and
Pierre Grammond, and
Vincent Van Pesch, and
Eugenio Pucci, and
François Grand'Maison, and
Raymond Hupperts, and
Franco Granella, and
Patrizia Sola, and
Roberto Bergamaschi, and
Gerardo Iuliano, and
Daniele Spitaleri, and
Cavit Boz, and
Suzanne Hodgkinson, and
Javier Olascoaga, and
Freek Verheul, and
Pamela McCombe, and
Thor Petersen, and
Csilla Rozsa, and
Jeannette Lechner-Scott, and
Maria Laura Saladino, and
Deborah Farina, and
Pietro Iaffaldano, and
Damiano Paolicelli, and
Helmut Butzkueven, and
Alessandra Lugaresi, and
Maria Trojano, and
March 2022,
Multiple sclerosis and related disorders,
Vilija G Jokubaitis, and
Tim Spelman, and
Tomas Kalincik, and
Johannes Lorscheider, and
Eva Havrdova, and
Dana Horakova, and
Pierre Duquette, and
Marc Girard, and
Alexandre Prat, and
Guillermo Izquierdo, and
Pierre Grammond, and
Vincent Van Pesch, and
Eugenio Pucci, and
François Grand'Maison, and
Raymond Hupperts, and
Franco Granella, and
Patrizia Sola, and
Roberto Bergamaschi, and
Gerardo Iuliano, and
Daniele Spitaleri, and
Cavit Boz, and
Suzanne Hodgkinson, and
Javier Olascoaga, and
Freek Verheul, and
Pamela McCombe, and
Thor Petersen, and
Csilla Rozsa, and
Jeannette Lechner-Scott, and
Maria Laura Saladino, and
Deborah Farina, and
Pietro Iaffaldano, and
Damiano Paolicelli, and
Helmut Butzkueven, and
Alessandra Lugaresi, and
Maria Trojano, and
November 2018,
JAMA neurology,
Vilija G Jokubaitis, and
Tim Spelman, and
Tomas Kalincik, and
Johannes Lorscheider, and
Eva Havrdova, and
Dana Horakova, and
Pierre Duquette, and
Marc Girard, and
Alexandre Prat, and
Guillermo Izquierdo, and
Pierre Grammond, and
Vincent Van Pesch, and
Eugenio Pucci, and
François Grand'Maison, and
Raymond Hupperts, and
Franco Granella, and
Patrizia Sola, and
Roberto Bergamaschi, and
Gerardo Iuliano, and
Daniele Spitaleri, and
Cavit Boz, and
Suzanne Hodgkinson, and
Javier Olascoaga, and
Freek Verheul, and
Pamela McCombe, and
Thor Petersen, and
Csilla Rozsa, and
Jeannette Lechner-Scott, and
Maria Laura Saladino, and
Deborah Farina, and
Pietro Iaffaldano, and
Damiano Paolicelli, and
Helmut Butzkueven, and
Alessandra Lugaresi, and
Maria Trojano, and
March 2023,
Multiple sclerosis (Houndmills, Basingstoke, England),
Vilija G Jokubaitis, and
Tim Spelman, and
Tomas Kalincik, and
Johannes Lorscheider, and
Eva Havrdova, and
Dana Horakova, and
Pierre Duquette, and
Marc Girard, and
Alexandre Prat, and
Guillermo Izquierdo, and
Pierre Grammond, and
Vincent Van Pesch, and
Eugenio Pucci, and
François Grand'Maison, and
Raymond Hupperts, and
Franco Granella, and
Patrizia Sola, and
Roberto Bergamaschi, and
Gerardo Iuliano, and
Daniele Spitaleri, and
Cavit Boz, and
Suzanne Hodgkinson, and
Javier Olascoaga, and
Freek Verheul, and
Pamela McCombe, and
Thor Petersen, and
Csilla Rozsa, and
Jeannette Lechner-Scott, and
Maria Laura Saladino, and
Deborah Farina, and
Pietro Iaffaldano, and
Damiano Paolicelli, and
Helmut Butzkueven, and
Alessandra Lugaresi, and
Maria Trojano, and
January 2021,
Multiple sclerosis journal - experimental, translational and clinical,
Vilija G Jokubaitis, and
Tim Spelman, and
Tomas Kalincik, and
Johannes Lorscheider, and
Eva Havrdova, and
Dana Horakova, and
Pierre Duquette, and
Marc Girard, and
Alexandre Prat, and
Guillermo Izquierdo, and
Pierre Grammond, and
Vincent Van Pesch, and
Eugenio Pucci, and
François Grand'Maison, and
Raymond Hupperts, and
Franco Granella, and
Patrizia Sola, and
Roberto Bergamaschi, and
Gerardo Iuliano, and
Daniele Spitaleri, and
Cavit Boz, and
Suzanne Hodgkinson, and
Javier Olascoaga, and
Freek Verheul, and
Pamela McCombe, and
Thor Petersen, and
Csilla Rozsa, and
Jeannette Lechner-Scott, and
Maria Laura Saladino, and
Deborah Farina, and
Pietro Iaffaldano, and
Damiano Paolicelli, and
Helmut Butzkueven, and
Alessandra Lugaresi, and
Maria Trojano, and
January 2014,
Multiple sclerosis (Houndmills, Basingstoke, England),
Vilija G Jokubaitis, and
Tim Spelman, and
Tomas Kalincik, and
Johannes Lorscheider, and
Eva Havrdova, and
Dana Horakova, and
Pierre Duquette, and
Marc Girard, and
Alexandre Prat, and
Guillermo Izquierdo, and
Pierre Grammond, and
Vincent Van Pesch, and
Eugenio Pucci, and
François Grand'Maison, and
Raymond Hupperts, and
Franco Granella, and
Patrizia Sola, and
Roberto Bergamaschi, and
Gerardo Iuliano, and
Daniele Spitaleri, and
Cavit Boz, and
Suzanne Hodgkinson, and
Javier Olascoaga, and
Freek Verheul, and
Pamela McCombe, and
Thor Petersen, and
Csilla Rozsa, and
Jeannette Lechner-Scott, and
Maria Laura Saladino, and
Deborah Farina, and
Pietro Iaffaldano, and
Damiano Paolicelli, and
Helmut Butzkueven, and
Alessandra Lugaresi, and
Maria Trojano, and
January 2012,
Multiple sclerosis (Houndmills, Basingstoke, England),
