BIOMAT Database Logo BIOMAT Database Logo

Radiosynthesis and preliminary biological evaluation of N-(2-[18F]fluoropropionyl)-L-glutamine as a PET tracer for tumor imaging. 2016

Caihua Tang, and Ganghua Tang, and Siyuan Gao, and Shaoyu Liu, and Fuhua Wen, and Baoguo Yao, and Dahong Nie
PET-CT Center, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, P.R. China.

In this study, radiosynthesis and biological evaluation of a new [18F]labeled glutamine analogue, N-(2-[18F]fluoropropionyl)-L-glutamine ([18F]FPGLN) for tumor PET imaging are performed. [18F]FPGLN was synthesized via a two-step reaction sequence from 4-nitrophenyl-2-[18F]fluoropropionate ([18F]NFP) with a decay-corrected yield of 30 ± 5% (n=10) and a specific activity of 48 ± 10 GBq/μmol after 125 ± 5 min of radiosynthesis. The biodistribution of [18F]FPGLN was determined in normal Kunming mice and high uptake of [18F]FPGLN was observed within the kidneys and quickly excreted through the urinary bladder. In vitro cell experiments showed that [18F]FPGLN was primarily transported by Na+-dependent system XAG- and was not incorporated into proteins. [18F]FPGLN displayed better stability in vitro than that in vivo. PET/CT studies revealed that intense accumulation of [18F]FPGLN were shown in human SPC-A-1 lung adenocarcinoma and PC-3 prostate cancer xenografts. The results support that [18F]FPGLN seems to be a possible PET tracer for tumor imaging.

UI MeSH Term Description Entries
D005462 Fluorine Radioisotopes Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes. Radioisotopes, Fluorine
D005973 Glutamine A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells. D-Glutamine,L-Glutamine,D Glutamine,L Glutamine
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014018 Tissue Distribution Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D049268 Positron-Emission Tomography An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower. PET Imaging,PET Scan,Positron-Emission Tomography Imaging,Tomography, Positron-Emission,Imaging, PET,Imaging, Positron-Emission Tomography,PET Imagings,PET Scans,Positron Emission Tomography,Positron Emission Tomography Imaging,Positron-Emission Tomography Imagings,Scan, PET,Tomography Imaging, Positron-Emission,Tomography, Positron Emission
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D019275 Radiopharmaceuticals Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) Radiopharmaceutical
D064593 Heterografts Tissues, cells or organs transplanted between animals of different species. Xenografts,Heterograft,Xenograft

Related Publications

Caihua Tang, and Ganghua Tang, and Siyuan Gao, and Shaoyu Liu, and Fuhua Wen, and Baoguo Yao, and Dahong Nie
Radiosynthesis and evaluation of N5-(2-18F-fluoropropanyl) ornithine as a potential agent for tumor PET imaging.
January 2021, Nuclear medicine and biology,
Caihua Tang, and Ganghua Tang, and Siyuan Gao, and Shaoyu Liu, and Fuhua Wen, and Baoguo Yao, and Dahong Nie
Radiosynthesis and Biological Evaluation of [18F]Triacoxib: A New Radiotracer for PET Imaging of COX-2.
January 2020, Molecular pharmaceutics,
Caihua Tang, and Ganghua Tang, and Siyuan Gao, and Shaoyu Liu, and Fuhua Wen, and Baoguo Yao, and Dahong Nie
Re(CO)3([18F]FEDA), a novel 18F PET renal tracer: Radiosynthesis and preclinical evaluation.
March 2018, Nuclear medicine and biology,
Caihua Tang, and Ganghua Tang, and Siyuan Gao, and Shaoyu Liu, and Fuhua Wen, and Baoguo Yao, and Dahong Nie
Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters.
April 1997, Nuclear medicine and biology,
Caihua Tang, and Ganghua Tang, and Siyuan Gao, and Shaoyu Liu, and Fuhua Wen, and Baoguo Yao, and Dahong Nie
Radiosynthesis and Biological Evaluation of [18F]R91150, a Selective 5-HT2A Receptor Antagonist for PET-Imaging.
May 2021, ACS medicinal chemistry letters,
Caihua Tang, and Ganghua Tang, and Siyuan Gao, and Shaoyu Liu, and Fuhua Wen, and Baoguo Yao, and Dahong Nie
Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors.
June 2013, Bioorganic & medicinal chemistry letters,
Caihua Tang, and Ganghua Tang, and Siyuan Gao, and Shaoyu Liu, and Fuhua Wen, and Baoguo Yao, and Dahong Nie
Whole-body tumor imaging using PET and 2-18F-fluoro-L-tyrosine: preliminary evaluation and comparison with 18F-FDG.
April 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Caihua Tang, and Ganghua Tang, and Siyuan Gao, and Shaoyu Liu, and Fuhua Wen, and Baoguo Yao, and Dahong Nie
Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [18F]fluorophenylglutamine and [18F]fluorobiphenylglutamine.
January 2020, Nuclear medicine and biology,
Caihua Tang, and Ganghua Tang, and Siyuan Gao, and Shaoyu Liu, and Fuhua Wen, and Baoguo Yao, and Dahong Nie
Radiosynthesis and Preliminary Biological Evaluation of [18F]VC701, a Radioligand for Translocator Protein.
January 2015, Molecular imaging,
Caihua Tang, and Ganghua Tang, and Siyuan Gao, and Shaoyu Liu, and Fuhua Wen, and Baoguo Yao, and Dahong Nie
Evaluation of 2-deoxy-2-[18F]fluoro glucaric acid (FGA) as a potential PET tracer for tumor necrosis.
October 2023, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Copied contents to your clipboard!