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Many studies have explored the use of (18)F-flurodeoxyglucose (FDG-PET) with CT for radiation therapy planning. The addition of PET/CT could improve tumor volume delineation, reduce geographic misses, and decrease treatment-related toxicity. For cancers of the gastrointestinal tract, the potential benefit of FDG-PET in radiation therapy management is less frequently studied. This article reviews the literature concerning PET/CT in radiation treatment planning. PET/CT appears to have an impact on tumor volume definition. More studies are needed to determine the impact of PET/CT-based radiation therapy on local control, patterns of failure, and treatment-related toxicity.
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