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Maternal and fetal circulating prolactin (PRL) increases 10-fold compared with the non-pregnant state. We examined the effect of PRL upon placental steroidogenesis. It had a significant (P less than 0.05) time-dependent stimulatory effect upon placental explants/P4 accumulation and secretion into the medium. The maximal stimulatory effect (two-fold) in dose-dependent experiments was found to be 200 ng/ml. The effect of PRL upon oestradiol secretion was mainly inhibitory. This inhibition was most pronounced at 200 ng/ml. In conclusion, placental steroid secretion is modulated by PRL. This effect occurs mainly at concentrations seen in the placenta at term, suggestive of its physiologic role.
E R Barnea, and
F Fares, and
K Shahar
November 1980,
Fertility and sterility,
E R Barnea, and
F Fares, and
K Shahar
September 2018,
Journal of neuroendocrinology,
E R Barnea, and
F Fares, and
K Shahar
August 1989,
Endocrinologia japonica,
E R Barnea, and
F Fares, and
K Shahar
July 1982,
Clinical endocrinology,
E R Barnea, and
F Fares, and
K Shahar
November 1981,
The Journal of clinical endocrinology and metabolism,
E R Barnea, and
F Fares, and
K Shahar
July 1993,
Obstetrics and gynecology,
E R Barnea, and
F Fares, and
K Shahar
July 2005,
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
E R Barnea, and
F Fares, and
K Shahar
January 1983,
Placenta,
E R Barnea, and
F Fares, and
K Shahar
April 1995,
General and comparative endocrinology,
E R Barnea, and
F Fares, and
K Shahar
June 1988,
The Journal of endocrinology,
