OBJECTIVE The aim of this study was to analyze age-dependent lumbar puncture pressures (LPPs) measured in 262 children with craniosynostosis to provide information that assists in determining surgery. METHODS From 1 July 2005 to 30 June 2014, 262 children with craniosynostosis diagnosed at the Department of Neurosurgery, Ajou University Hospital, underwent LPP measurement. These children were compared with respect to age, gender, birth weight, head circumference at the time of birth, gestational age, LPP, and developmental assessments. RESULTS Changes in LPP in children with craniosynostosis according to age were y = -0.0007x(2) + 0.1327x + 21.678 in all patients overall, y = -0.0003x(2) + 0.1166x + 21.466 in children with single-suture craniosynostosis, and y = -0.002x(2) + 0.248x + 22.55 in patients with multiple and syndromic craniosynostosis, indicating a steady and slow increase from birth until the age of 4 years. Also, 59.9% of the 262 children had LPP greater than 20 cm H2O, but when the LPP cutoff level was adjusted for age, this proportion was 99.2%; the new criterion after the adjusted LPP cutoff level showed that for those with increased LPP, the proportion was 63.4%. CONCLUSIONS We suggest that LPP increases slowly with age in children with craniosynostosis, increased LPP rates in children with craniosynostosis were higher than previously expected, and the new cutoff level criterion that adjusts for age may be more helpful than a fixed cutoff level for all ages.