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Photodynamic action of protoporphyrin IX derivatives on Trichophyton rubrum. 2016

Rogério Rodrigo Ramos, and Dora Inês Kozusny-Andreani, and Adjaci Uchôa Fernandes, and Mauricio da Silva Baptista
Fundação Educacional de Fernandópolis, Fernandópolis, SP, Brazil.

BACKGROUND Dermatophytes are filamentous keratinophilic fungi. Trichophyton rubrum is a prevalent infectious agent in tineas and other skin diseases. Drug therapy is considered to be limited in the treatment of such infections, mainly due to low accessibility of the drug to the tissue attacked and development of antifungal resistance in these microorganisms. In this context, Photodynamic Therapy is presented as an alternative. OBJECTIVE Evaluate, in vitro, the photodynamic activity of four derivatives of Protoporphyrin IX by irradiation with LED 400 nm in T. rubrum. METHODS Assays were subjected to irradiation by twelve cycles of ten minutes at five minute intervals. RESULTS Photodynamic action appeared as effective with total elimination of UFCs from the second irradiation cycle. CONCLUSIONS Studies show that the photodynamic activity on Trichophyton rubrum relates to a suitable embodiment of the photosensitizer, which can be maximized by functionalization of peripheral groups of the porphyrinic ring.

UI MeSH Term Description Entries
D010778 Photochemotherapy Therapy using oral or topical photosensitizing agents with subsequent exposure to light. Blue Light Photodynamic Therapy,Photodynamic Therapy,Red Light PDT,Red Light Photodynamic Therapy,Therapy, Photodynamic,Light PDT, Red,PDT, Red Light,Photochemotherapies,Photodynamic Therapies,Therapies, Photodynamic
D011524 Protoporphyrins Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D003883 Arthrodermataceae A family of ascomycetous fungi, order Onygenales, characterized by smooth ascospores. Genera in the family include Arthroderma, Keratinomyces, and Ctenomyces. Several well-known anamorphic forms are parasitic upon the skin. Arthroderma,Ctenomyces,Dermatophytes,Keratinomyces,Cutaneous Fungi,Cutaneous Fungus,Dermatomyces,Nannizzia,Arthrodermas,Ctenomyce,Dermatomyce,Dermatophyte,Fungi, Cutaneous,Fungus, Cutaneous,Keratinomyce,Nannizzias
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D000935 Antifungal Agents Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. Anti-Fungal Agents,Antifungal Agent,Fungicides, Therapeutic,Antibiotics, Antifungal,Therapeutic Fungicides,Agent, Antifungal,Anti Fungal Agents,Antifungal Antibiotics
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014005 Tinea Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON. Dermatophytoses,Epidermophytosis,Ringworm,Tinea Corporis,Trichophytosis,Dermatophytosis,Trichophyton mentagrophytes Infection,Epidermophytoses,Infection, Trichophyton mentagrophytes,Tineas,Trichophyton mentagrophytes Infections,Trichophytoses
D014249 Trichophyton A mitosporic fungal genus and an anamorphic form of Arthroderma. Various species attack the skin, nails, and hair. Endodermophyton,Trychophyton,Endodermophytons,Trichophytons,Trychophytons
D015169 Colony Count, Microbial Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing. Agar Dilution Count,Colony-Forming Units Assay, Microbial,Fungal Count,Pour Plate Count,Spore Count,Spread Plate Count,Streak Plate Count,Colony Forming Units Assay, Microbial,Colony Forming Units Assays, Microbial,Agar Dilution Counts,Colony Counts, Microbial,Count, Agar Dilution,Count, Fungal,Count, Microbial Colony,Count, Pour Plate,Count, Spore,Count, Spread Plate,Count, Streak Plate,Counts, Agar Dilution,Counts, Fungal,Counts, Microbial Colony,Counts, Pour Plate,Counts, Spore,Counts, Spread Plate,Counts, Streak Plate,Dilution Count, Agar,Dilution Counts, Agar,Fungal Counts,Microbial Colony Count,Microbial Colony Counts,Pour Plate Counts,Spore Counts,Spread Plate Counts,Streak Plate Counts

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