BIOMAT Database Logo BIOMAT Database Logo

Penetration of the fragrance compounds, cinnamaldehyde and cinnamyl alcohol, through human skin in vitro. 1989

H Weibel, and J Hansen
Pharmaceutical Research and Development Department, Pharmacia AS, Hillerød, Denmark.

The delivery of cinnamaldehyde and cinnamyl alcohol in fragrance through human skin has been investigated by in vitro penetration studies using full thickness human skin. Cinnamaldehyde was transformed to cinnamyl alcohol and cinnamic acid in the skin. The transformation took place in model protein solution, bovine serum albumin, as well as in skin homogenates. After conjugation of cinnamaldehyde with the protein, a lag time was observed after which cinnamyl alcohol and cinnamic acid were released. On the other hand, cinnamyl alcohol was not transformed in detectable amounts to either cinnamaldehyde or cinnamic acid during penetration of the skin.

UI MeSH Term Description Entries
D010476 Perfume A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell, especially a fluid containing fragrant natural oils extracted from flowers, woods, etc., or similar synthetic oils. (Random House Unabridged Dictionary, 2d ed)
D010539 Permeability Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions. Permeabilities
D000171 Acrolein Unsaturated three-carbon aldehyde. 2-Propenal,Acraldehyde,Acrylaldehyde,Acrylic Aldehyde,Allyl Aldehyde,Aqualin,Ethylene Aldehyde,2 Propenal,Aldehyde, Acrylic,Aldehyde, Allyl,Aldehyde, Ethylene
D000433 1-Propanol A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate. Alcohol, Propyl,Propanol,n-Propanol,Propyl Alcohol
D000447 Aldehydes Organic compounds containing a carbonyl group in the form -CHO. Aldehyde
D001711 Biotransformation The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D012710 Serum Albumin, Bovine Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed) Fetal Bovine Serum,Fetal Calf Serum,Albumin Bovine,Bovine Albumin,Bovine Serum Albumin,Albumin, Bovine,Albumin, Bovine Serum,Bovine Serum, Fetal,Bovine, Albumin,Calf Serum, Fetal,Serum, Fetal Bovine,Serum, Fetal Calf
D012869 Skin Absorption Uptake of substances through the SKIN. Absorption, Skin,Intracutaneous Absorption,Intradermal Absorption,Percutaneous Absorption,Transcutaneous Absorption,Transdermal Absorption,Absorption, Intracutaneous,Absorption, Intradermal,Absorption, Percutaneous,Absorption, Transcutaneous,Absorption, Transdermal,Absorptions, Intracutaneous,Absorptions, Intradermal,Absorptions, Percutaneous,Absorptions, Skin,Absorptions, Transcutaneous,Absorptions, Transdermal,Intracutaneous Absorptions,Intradermal Absorptions,Percutaneous Absorptions,Skin Absorptions,Transcutaneous Absorptions,Transdermal Absorptions
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D020005 Propanols Isomeric forms and derivatives of PROPANOL (C3H7OH). Alcohols, Propyl,Propyl Alcohols

Related Publications

H Weibel, and J Hansen
Penetration of fragrance compounds through human epidermis.
June 1983, The Journal of dermatology,
H Weibel, and J Hansen
In-vitro human skin penetration of the fragrance material geranyl nitrile.
February 2007, Toxicology in vitro : an international journal published in association with BIBRA,
H Weibel, and J Hansen
A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients.
June 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
H Weibel, and J Hansen
Fragrance material review on cinnamyl alcohol.
June 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
H Weibel, and J Hansen
In Situ Metabolism of Cinnamyl Alcohol in Reconstructed Human Epidermis: New Insights into the Activation of This Fragrance Skin Sensitizer.
July 2016, Chemical research in toxicology,
H Weibel, and J Hansen
Dermal penetration of ethylene glycol through human skin in vitro.
January 2010, International journal of toxicology,
H Weibel, and J Hansen
Penetration of ammonium perfluorooctanoate through rat and human skin in vitro.
January 2005, Drug and chemical toxicology,
H Weibel, and J Hansen
Cofactor recycling for selective enzymatic biotransformation of cinnamaldehyde to cinnamyl alcohol.
May 2009, Bioscience, biotechnology, and biochemistry,
H Weibel, and J Hansen
Oxidation of organic compounds with xenon trioxide I. Stoichiometric and kinetic studies involving cinnamyl alcohol, cinnamaldehyde, and cinnamic acid.
October 1968, Journal of pharmaceutical sciences,
H Weibel, and J Hansen
The in vitro penetration and distribution of T-2 toxin through human skin.
July 1986, Toxicology,
Copied contents to your clipboard!