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Enumerating pelvic recurrence following radical cystectomy for bladder cancer: A Canadian multi-institutional study. 2016
Libni J Eapen, and
Edward Jones, and
Wassim Kassouf, and
Carole Lambert, and
Scott C Morgan, and
Madeleine Moussa, and
Robert Nam, and
Matthew Parliament, and
Laurie Russell, and
Fred Saad, and
D Robert Siemens, and
Luis Souhami, and
Ewa Szumacher, and
Scott Tyldesley, and
Yan Xu, and
Ingrid Zbieranowski, and
Rodney H Breau, and
Eric Belanger, and
Peter Black, and
Eric Estey, and
Julie Bowan, and
Bishwajit Bora, and
Michael Brundage, and
Peter Chung, and
Neil Fleshner, and
Andrew Evans, and
Glenn Bauman, and
Jonathan Izawa, and
Chris Davidson, and
Fadi Brimo
The Ottawa Hospital Cancer Centre, University of Ottawa, Ottawa, ON, Canada;
BACKGROUND We aimed to enumerate the rate of pelvic recurrence following radical cystectomy at university-affiliated hospitals in Canada. METHODS Canadian, university-affiliated hospitals were invited to participate. They were asked to identify the first 10 consecutive patients undergoing radical cystectomy starting January 1, 2005, who had urothelial carcinoma stages pT3/T4 N0-2 M0. The first 10 consecutive cases starting January 1, 2005 who met these criteria were the patients submitted by that institution with information regarding tumour stage, age, number of nodes removed, and last known clinical status in regard to recurrence and patterns of failure. RESULTS Of the 111 patients, 80% had pT3 and 20% pT4 disease, with 62% being node-negative, 14% pN1, and 27% pN2; 57% had 10 or more nodes removed. Cumulative incidence of pelvic relapse was 40% among the entire group. CONCLUSIONS This review demonstrates a high rate of pelvic tumour recurrence following radical cystectomy for pT3/T4 urothelial cancer.
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