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The bioavailability and absorption pattern of theophylline from Theolong granule and Theodur-G were studied in five healthy volunteers both in fasting conditions and after taking two different meals. In all the subjects, no dose-dumping effect was observed with a standard- or a fat-rich breakfast on these preparations. Postprandial administration delayed the absorption of theophylline and a fat-rich breakfast significantly reduced the area under the curve (AUC0-26) for both preparations. The mean AUC decreased by 14.0% for the former and 19.7% for the latter when the fat-rich breakfast was administered. Intake of a standard breakfast resulted in a decrease in the AUC0-26 by 10.6% for Theolong granules but there was little effect observed with the Theodur-G granules.
H Tada, and
M Ishikawa, and
E Sato, and
T Suzuki, and
K Unno, and
K Miura, and
Y Ohmiya, and
K Nakai
February 1987,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
H Tada, and
M Ishikawa, and
E Sato, and
T Suzuki, and
K Unno, and
K Miura, and
Y Ohmiya, and
K Nakai
August 1988,
International journal of clinical pharmacology, therapy, and toxicology,
H Tada, and
M Ishikawa, and
E Sato, and
T Suzuki, and
K Unno, and
K Miura, and
Y Ohmiya, and
K Nakai
October 1986,
The Journal of allergy and clinical immunology,
H Tada, and
M Ishikawa, and
E Sato, and
T Suzuki, and
K Unno, and
K Miura, and
Y Ohmiya, and
K Nakai
October 1987,
Clinical pharmacokinetics,
H Tada, and
M Ishikawa, and
E Sato, and
T Suzuki, and
K Unno, and
K Miura, and
Y Ohmiya, and
K Nakai
July 1991,
Arzneimittel-Forschung,
H Tada, and
M Ishikawa, and
E Sato, and
T Suzuki, and
K Unno, and
K Miura, and
Y Ohmiya, and
K Nakai
December 2003,
Bollettino chimico farmaceutico,
H Tada, and
M Ishikawa, and
E Sato, and
T Suzuki, and
K Unno, and
K Miura, and
Y Ohmiya, and
K Nakai
March 1994,
Arzneimittel-Forschung,
H Tada, and
M Ishikawa, and
E Sato, and
T Suzuki, and
K Unno, and
K Miura, and
Y Ohmiya, and
K Nakai
October 1982,
Allergy,
H Tada, and
M Ishikawa, and
E Sato, and
T Suzuki, and
K Unno, and
K Miura, and
Y Ohmiya, and
K Nakai
March 1990,
Biopharmaceutics & drug disposition,
H Tada, and
M Ishikawa, and
E Sato, and
T Suzuki, and
K Unno, and
K Miura, and
Y Ohmiya, and
K Nakai
January 1986,
Therapie,
