BIOMAT Database Logo BIOMAT Database Logo

Synthesis, anti-proliferative and genotoxicity studies of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones and 6-chloro-5-(2-chloroethyl)-3-(alkyl/ary-2-ylidene)indolin-2-ones. 2016

Gangadhar Y Meti, and Atulkumar A Kamble, and Ravindra R Kamble, and Shilpa M Somagond, and H C Devarajegowda, and Sandhya Kumari, and Guruprasad Kalthur, and Satish K Adiga
R. L. Fine Chemicals Ltd. Yelahanka, Bangalore 560064, India.

A series of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones (3a-h) and 6-chloro-5-(2-chloroethyl)-3-(alkyl/aryl-2-ylidene)indolin-2-ones (5i-x) were synthesized. Compounds 3a-e, 5i-l and 5q-r were selected by NIH, USA for in vitro anti-proliferative screening. Based on the impressive growth inhibitory (GI %) effect by the compounds 3a-b and 3e which showed growth inhibition in the range 1.22-76.30%, 2.85-76.03% and 10.98-82.05% respectively at 10(-5) concentration, these compounds were further analyzed for anti-proliferative activity at 5 dose concentration and genotoxicity.

UI MeSH Term Description Entries
D007211 Indoles Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D045744 Cell Line, Tumor A cell line derived from cultured tumor cells. Tumor Cell Line,Cell Lines, Tumor,Line, Tumor Cell,Lines, Tumor Cell,Tumor Cell Lines
D049109 Cell Proliferation All of the processes involved in increasing CELL NUMBER including CELL DIVISION. Cell Growth in Number,Cellular Proliferation,Cell Multiplication,Cell Number Growth,Growth, Cell Number,Multiplication, Cell,Number Growth, Cell,Proliferation, Cell,Proliferation, Cellular

Related Publications

Gangadhar Y Meti, and Atulkumar A Kamble, and Ravindra R Kamble, and Shilpa M Somagond, and H C Devarajegowda, and Sandhya Kumari, and Guruprasad Kalthur, and Satish K Adiga
6-Substituted 5-chloro-1,3-dihydro-2H-imidazo(4,5-b)pyrazin-2-ones with hypotensive activity.
May 1973, Journal of medicinal chemistry,
Gangadhar Y Meti, and Atulkumar A Kamble, and Ravindra R Kamble, and Shilpa M Somagond, and H C Devarajegowda, and Sandhya Kumari, and Guruprasad Kalthur, and Satish K Adiga
Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones.
February 2009, Dalton transactions (Cambridge, England : 2003),
Gangadhar Y Meti, and Atulkumar A Kamble, and Ravindra R Kamble, and Shilpa M Somagond, and H C Devarajegowda, and Sandhya Kumari, and Guruprasad Kalthur, and Satish K Adiga
3-Substituted, 3-(4-pyridinylmethyl)-1,3-dihydro-1-phenyl-2H-indol-2-ones as acetylcholine release enhancers: synthesis and SAR.
October 1993, Journal of medicinal chemistry,
Gangadhar Y Meti, and Atulkumar A Kamble, and Ravindra R Kamble, and Shilpa M Somagond, and H C Devarajegowda, and Sandhya Kumari, and Guruprasad Kalthur, and Satish K Adiga
Synthesis of 2-Mercapto-(2-Oxoindolin-3-Ylidene)Acetonitriles from 3-(4-Chloro-5H-1,2,3-Dithiazol-5-Ylidene)Indolin-2-ones.
June 2018, Molecules (Basel, Switzerland),
Gangadhar Y Meti, and Atulkumar A Kamble, and Ravindra R Kamble, and Shilpa M Somagond, and H C Devarajegowda, and Sandhya Kumari, and Guruprasad Kalthur, and Satish K Adiga
6-Bicycloaryl substituted (S)- and (R)-5,6-dihydro-2H-pyran-2-ones: asymmetric synthesis, and anti-proliferative properties.
January 2009, Bioorganic & medicinal chemistry,
Gangadhar Y Meti, and Atulkumar A Kamble, and Ravindra R Kamble, and Shilpa M Somagond, and H C Devarajegowda, and Sandhya Kumari, and Guruprasad Kalthur, and Satish K Adiga
[Synthesis and cardiotonic activities of 5-substituted-4-methyl-1,3- dihydro-2H-imidazol-2-ones].
January 1988, Yao xue xue bao = Acta pharmaceutica Sinica,
Gangadhar Y Meti, and Atulkumar A Kamble, and Ravindra R Kamble, and Shilpa M Somagond, and H C Devarajegowda, and Sandhya Kumari, and Guruprasad Kalthur, and Satish K Adiga
3,3'-Ethyl-enebis(3,4-dihydro-6-chloro-2H-1,3-benzoxazine).
April 2010, Acta crystallographica. Section E, Structure reports online,
Gangadhar Y Meti, and Atulkumar A Kamble, and Ravindra R Kamble, and Shilpa M Somagond, and H C Devarajegowda, and Sandhya Kumari, and Guruprasad Kalthur, and Satish K Adiga
Synthesis of (Z)-3-[amino(phenyl)methylidene]-1,3-dihydro-2H-indol-2-ones using an Eschenmoser coupling reaction.
January 2021, Beilstein journal of organic chemistry,
Gangadhar Y Meti, and Atulkumar A Kamble, and Ravindra R Kamble, and Shilpa M Somagond, and H C Devarajegowda, and Sandhya Kumari, and Guruprasad Kalthur, and Satish K Adiga
Synthesis of substituted 3-anilino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepine-2-ones and their evaluation as cholecystokinin-ligands.
April 2006, Archiv der Pharmazie,
Gangadhar Y Meti, and Atulkumar A Kamble, and Ravindra R Kamble, and Shilpa M Somagond, and H C Devarajegowda, and Sandhya Kumari, and Guruprasad Kalthur, and Satish K Adiga
Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors.
June 2011, Metallomics : integrated biometal science,
Copied contents to your clipboard!