Biomaterial Database

Exposure Variation and Endocrine Disruption of the Male Reproductive System. 2016

Jorma Toppari, and Wiwat Rodprasert, and Jaakko J Koskenniemi

Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland.

Exposure to endocrine disruptors varies geographically and temporally. Environmental levels of persistent organic pollutants have decreased after international regulation, whereas potential exposure to thousands of new chemicals has increased. The adverse effects of endocrine disruptors depend on susceptibility and timing of the exposure. Fetal and childhood exposures are often most harmful because of organizational and programming effects. In this review, we use the exposure to persistent organic pollutants such as polybrominated diphenyl ethers, dioxins and dioxin-like polychlorinated biphenyls and differences in the incidence of reproductive disorders between Denmark and Finland as an example to highlight how exposure variation and variation in genetic susceptibility may influence the strength of the association between the exposure to endocrine disruptors and adverse effects. Understanding the causes and implications of interindividual differences in susceptibility to endocrine disruptors is crucial for the protection of normal development.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D004147	Dioxins	A family of compounds that contain the 1,4-dioxin structure. Many specific dioxin derivatives are listed as CARCINOGENS; TERATOGENS; or MUTAGENS.	Dioxin
D004781	Environmental Exposure	The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.	Exposure, Environmental,Environmental Exposures,Exposures, Environmental
D005837	Genitalia, Male	The male reproductive organs. They are divided into the external organs (PENIS; SCROTUM; and URETHRA) and the internal organs (TESTIS; EPIDIDYMIS; VAS DEFERENS; SEMINAL VESICLES; EJACULATORY DUCTS; PROSTATE; and BULBOURETHRAL GLANDS).	Accessory Sex Organs, Male,Genital Organs, Male,Sex Organs, Accessory, Male,Genitals, Male,Reproductive System, Male,Genital, Male,Male Genital,Male Genital Organs,Male Genitalia,Male Genitals,Male Reproductive System,Male Reproductive Systems,Reproductive Systems, Male
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D052244	Endocrine Disruptors	Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism.	Endocrine Disrupting Chemical,Endocrine Disrupting Chemicals,Endocrine Disruptor,Endocrine Disruptor Effect,Endocrine Disruptor Effects,Chemical, Endocrine Disrupting,Chemicals, Endocrine Disrupting,Disrupting Chemical, Endocrine,Disruptor Effect, Endocrine,Disruptor Effects, Endocrine,Disruptor, Endocrine,Disruptors, Endocrine,Effect, Endocrine Disruptor,Effects, Endocrine Disruptor
D055768	Halogenated Diphenyl Ethers	Compounds that contain two halogenated benzene rings linked via an OXYGEN atom. Many polybrominated diphenyl ethers are used as FLAME RETARDANTS.	Brominated Diphenyl Ethers,Chlorinated Diphenyl Ethers,Fluorinated Diphenyl Ethers,Iodinated Diphenyl Ethers,PBDE Compounds,PBDEs,PCDE Compounds,PCDEs,Polybrominated Diphenyl Ethers,Diphenyl Ethers, Brominated,Diphenyl Ethers, Chlorinated,Diphenyl Ethers, Fluorinated,Diphenyl Ethers, Halogenated,Diphenyl Ethers, Iodinated,Diphenyl Ethers, Polybrominated,Ethers, Brominated Diphenyl,Ethers, Chlorinated Diphenyl,Ethers, Fluorinated Diphenyl,Ethers, Halogenated Diphenyl,Ethers, Iodinated Diphenyl,Ethers, Polybrominated Diphenyl