Biomaterial Database

Inhibition of glyoxalase I by new squaric acid derivatives. 1989

J L Kraus, and M Castaing

Laboratoire de Chimie Biomoléculaire - Faculté des Sciences de Luminy Case 901, Marseille.

Synthesis and antiglyoxalase activity of new squaric acid derivatives have been studied. It has been established that the substitution of one hydroxyl group of the squaric acid (1,2-dihydroxy cyclobutene 3,4-dione) by an N-substituted group decreased the antiglyoxalase activity while the corresponding - 2 methoxy substituted derivatives were comparatively equipotent.

UI	MeSH Term	Description	Entries
D007791	Lactoylglutathione Lyase	An enzyme that catalyzes the interconversion of methylglyoxal and lactate, with glutathione serving as a coenzyme. EC 4.4.1.5.	Glyoxalase I,Lactoyl Glutathione Lyase,Methylglyoxalase,Glutathione Lyase, Lactoyl,Lyase, Lactoyl Glutathione,Lyase, Lactoylglutathione
D008190	Lyases	A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.	Desmolase,Desmolases,Lyase
D002621	Chemistry	A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
D003503	Cyclobutanes	Four carbon cycloparaffin cyclobutane (the structural formula (CH2)4) and its derivatives.
D055598	Chemical Phenomena	The composition, structure, conformation, and properties of atoms and molecules, and their reaction and interaction processes.	Chemical Concepts,Chemical Processes,Physical Chemistry Concepts,Physical Chemistry Processes,Physicochemical Concepts,Physicochemical Phenomena,Physicochemical Processes,Chemical Phenomenon,Chemical Process,Physical Chemistry Phenomena,Physical Chemistry Process,Physicochemical Phenomenon,Physicochemical Process,Chemical Concept,Chemistry Process, Physical,Chemistry Processes, Physical,Concept, Chemical,Concept, Physical Chemistry,Concept, Physicochemical,Concepts, Chemical,Concepts, Physical Chemistry,Concepts, Physicochemical,Phenomena, Chemical,Phenomena, Physical Chemistry,Phenomena, Physicochemical,Phenomenon, Chemical,Phenomenon, Physicochemical,Physical Chemistry Concept,Physicochemical Concept,Process, Chemical,Process, Physical Chemistry,Process, Physicochemical,Processes, Chemical,Processes, Physical Chemistry,Processes, Physicochemical