Cytomegalovirus (CMV) Enzyme-Linked Immunosorbent Spot Assay but Not CMV QuantiFERON Assay Is a Novel Biomarker To Determine Risk of Congenital CMV Infection in Pregnant Women. 2016

Gabriella Forner, and Alda Saldan, and Carlo Mengoli, and Nadia Gussetti, and Giorgio Palù, and Davide Abate
Department of Molecular Medicine, University of Padua, Padua, Italy.

Cytomegalovirus (CMV) enzyme-linked immunosorbent spot (ELISPOT) and CMV QuantiFERON assays were examined as potential biomarkers predictive of congenital CMV (cCMV) transmission. Fifty-seven pregnant women with primary CMV infection and 23 with nonprimary CMV infection were recruited in the study. Maternal age, CMV IgG avidity, viremia, and viruria were also included among the potential predictors. Spearman's statistical correlation analysis revealed a positive correlation between the CMV ELISPOT and CMV QuantiFERON assay results (P < 0.001), but only the CMV ELISPOT assay correlated with cCMV (P < 0.001). cCMV was positively correlated with maternal viremia and viruria (P < 0.05) and negatively correlated with CMV IgG avidity (P < 0.01). Maternal age and CMV QuantiFERON assay results were not statistically associated with cCMV. CMV-specific cell-mediated immunity detected by the CMV ELISPOT assay plays a critical role in cCMV.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011251 Pregnancy Complications, Infectious The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION. Complications, Infectious Pregnancy,Infectious Pregnancy Complications,Maternal Sepsis,Pregnancy, Infectious Complications,Sepsis during Pregnancy,Sepsis in Pregnancy,Infectious Pregnancy Complication,Pregnancy Complication, Infectious,Sepsis in Pregnancies,Sepsis, Maternal
D003586 Cytomegalovirus Infections Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults. CMV Inclusion,CMV Inclusions,Congenital CMV Infection,Congenital Cytomegalovirus Infection,Cytomegalic Inclusion Disease,Cytomegalovirus Colitis,Cytomegalovirus Inclusion,Cytomegalovirus Inclusion Disease,Cytomegalovirus Inclusions,Inclusion Disease,Perinatal CMV Infection,Perinatal Cytomegalovirus Infection,Renal Tubular Cytomegalovirus Inclusion,Renal Tubular Cytomegalovirus Inclusions,Salivary Gland Virus Disease,Severe Cytomegalovirus Infection,Severe Cytomegalovirus Infections,Infections, Cytomegalovirus,CMV Infection, Congenital,CMV Infection, Perinatal,Colitis, Cytomegalovirus,Congenital CMV Infections,Congenital Cytomegalovirus Infections,Cytomegalic Inclusion Diseases,Cytomegalovirus Colitides,Cytomegalovirus Inclusion Diseases,Cytomegalovirus Infection,Cytomegalovirus Infection, Congenital,Cytomegalovirus Infection, Perinatal,Cytomegalovirus Infection, Severe,Cytomegalovirus Infections, Severe,Disease, Cytomegalic Inclusion,Disease, Cytomegalovirus Inclusion,Diseases, Cytomegalovirus Inclusion,Inclusion Disease, Cytomegalic,Inclusion Disease, Cytomegalovirus,Inclusion Diseases,Inclusion Diseases, Cytomegalovirus,Inclusion, CMV,Inclusion, Cytomegalovirus,Infection, Congenital CMV,Infection, Congenital Cytomegalovirus,Infection, Cytomegalovirus,Infection, Perinatal CMV,Infection, Perinatal Cytomegalovirus,Infection, Severe Cytomegalovirus,Perinatal CMV Infections,Perinatal Cytomegalovirus Infections
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D055815 Young Adult A person between 19 and 24 years of age. Adult, Young,Adults, Young,Young Adults
D058501 Enzyme-Linked Immunospot Assay A method of detection of the number of cells in a sample secreting a specific molecule. With this method, a population of cells are plated over top of the immunosorbent substrate that captures the secreted molecules. ELISPOT,Assay, Enzyme-Linked Immunospot,Assays, Enzyme-Linked Immunospot,Enzyme Linked Immunospot Assay,Enzyme-Linked Immunospot Assays,Immunospot Assay, Enzyme-Linked,Immunospot Assays, Enzyme-Linked

Related Publications

Gabriella Forner, and Alda Saldan, and Carlo Mengoli, and Nadia Gussetti, and Giorgio Palù, and Davide Abate
August 2013, Journal of clinical microbiology,
Gabriella Forner, and Alda Saldan, and Carlo Mengoli, and Nadia Gussetti, and Giorgio Palù, and Davide Abate
July 2021, Journal of clinical microbiology,
Gabriella Forner, and Alda Saldan, and Carlo Mengoli, and Nadia Gussetti, and Giorgio Palù, and Davide Abate
September 1982, Australian paediatric journal,
Gabriella Forner, and Alda Saldan, and Carlo Mengoli, and Nadia Gussetti, and Giorgio Palù, and Davide Abate
January 2023, Transplant international : official journal of the European Society for Organ Transplantation,
Gabriella Forner, and Alda Saldan, and Carlo Mengoli, and Nadia Gussetti, and Giorgio Palù, and Davide Abate
January 1982, Developments in biological standardization,
Gabriella Forner, and Alda Saldan, and Carlo Mengoli, and Nadia Gussetti, and Giorgio Palù, and Davide Abate
August 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Gabriella Forner, and Alda Saldan, and Carlo Mengoli, and Nadia Gussetti, and Giorgio Palù, and Davide Abate
February 1999, The American journal of tropical medicine and hygiene,
Gabriella Forner, and Alda Saldan, and Carlo Mengoli, and Nadia Gussetti, and Giorgio Palù, and Davide Abate
December 2013, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases,
Gabriella Forner, and Alda Saldan, and Carlo Mengoli, and Nadia Gussetti, and Giorgio Palù, and Davide Abate
July 2014, Domestic animal endocrinology,
Gabriella Forner, and Alda Saldan, and Carlo Mengoli, and Nadia Gussetti, and Giorgio Palù, and Davide Abate
March 2013, Journal of virological methods,
Copied contents to your clipboard!