BIOMAT Database Logo BIOMAT Database Logo

IgG Avidity: an Important Serologic Marker for the Diagnosis of Tick-Borne Encephalitis Virus Infection. 2016

Tatjana Vilibic-Cavlek, and Ljubo Barbic, and Vladimir Stevanovic, and Goranka Petrovic, and Gordana Mlinaric-Galinovic

A total of 52 serum samples from patients with symptoms suggestive of tick-borne encephalitis virus (TBEV) infection and positive IgM and/or IgG antibodies were tested for IgG avidity. Acute/recent TBEV infection was confirmed by low/borderline avidity index (AI) in 94.8% IgM positive/IgG positive samples, while in 5.2% high AI was found indicating persisting IgM antibodies. Majority of IgM negative/IgG positive samples (78.6%) showed high AI consistent with past TBEV infection. However, in 21.3% patients without measurable IgM antibodies current/recent infection was confirmed by AI. IgG avidity represents an additional serologic marker that improves diagnosis of TBEV, especially in cases of atypical antibody response.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007075 Immunoglobulin M A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin. Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D004669 Encephalitis Viruses, Tick-Borne A subgroup of the genus FLAVIVIRUS that causes encephalitis and hemorrhagic fevers and is found in eastern and western Europe and the former Soviet Union. It is transmitted by TICKS and there is an associated milk-borne transmission from viremic cattle, goats, and sheep. Hemorrhagic Fever Virus, Omsk,Kyasanur Forest disease virus,Langat virus,Louping ill virus,Omsk hemorrhagic fever virus,Powassan virus,Al-Khurma Hemorrhagic Fever Virus,Al-Khurma virus,Al-Khurma virus (ALKV),Alkhurma Hemorrhagic Fever Virus,Alkhurma virus,Alkhurma virus (ALKV),Encephalitis Virus, Tick-Borne,Tick-Borne Encephalitis Virus,Tick-Borne Encephalitis Viruses,Viruses, Tick-Borne Encephalitis,Al Khurma Hemorrhagic Fever Virus,Al Khurma virus,Al Khurma virus (ALKV),Encephalitis Virus, Tick Borne,Encephalitis Viruses, Tick Borne,Louping ill viruses,Tick Borne Encephalitis Virus,Tick Borne Encephalitis Viruses
D004675 Encephalitis, Tick-Borne Encephalitis caused by neurotropic viruses that are transmitted via the bite of TICKS. In Europe, the diseases are caused by ENCEPHALITIS VIRUSES, TICK-BORNE, which give rise to Russian spring-summer encephalitis, central European encephalitis, louping ill encephalitis, and related disorders. Powassan encephalitis occurs in North America and Russia and is caused by the Powassan virus. ASEPTIC MENINGITIS and rarely encephalitis may complicate COLORADO TICK FEVER which is endemic to mountainous regions of the western United States. (From Joynt, Clinical Neurology, 1996, Ch26, pp14-5) Far Eastern Russian Encephalitis,Powassan Encephalitis,Central European Encephalitis,Encephalitis, Central European,Encephalitis, European Tick-Borne,Encephalitis, Far Eastern Russian,Encephalitis, Louping Ill,Encephalitis, Russian Spring-Summer,European Tick-Borne Encephalitis,Louping Ill Encephalitis,Powassan Virus Disease,Russian Spring-Summer Encephalitis,Tick-Borne Encephalitis,Disease, Powassan Virus,Encephalitis, European Tick Borne,Encephalitis, Powassan,Encephalitis, Russian Spring Summer,Encephalitis, Tick Borne,European Tick Borne Encephalitis,Powassan Encephalitides,Powassan Virus Diseases,Russian Spring Summer Encephalitis,Spring-Summer Encephalitis, Russian,Tick Borne Encephalitis,Tick-Borne Encephalitis, European,Virus Disease, Powassan,Virus Diseases, Powassan
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000914 Antibodies, Viral Immunoglobulins produced in response to VIRAL ANTIGENS. Viral Antibodies
D000915 Antibody Affinity A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes. Affinity, Antibody,Antibody Avidity,Avidity, Antibody,Affinities, Antibody,Antibody Affinities,Antibody Avidities,Avidities, Antibody
D015415 Biomarkers Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, ENVIRONMENTAL EXPOSURE and its effects, disease diagnosis; METABOLIC PROCESSES; SUBSTANCE ABUSE; PREGNANCY; cell line development; EPIDEMIOLOGIC STUDIES; etc. Biochemical Markers,Biological Markers,Biomarker,Clinical Markers,Immunologic Markers,Laboratory Markers,Markers, Biochemical,Markers, Biological,Markers, Clinical,Markers, Immunologic,Markers, Laboratory,Markers, Serum,Markers, Surrogate,Markers, Viral,Serum Markers,Surrogate Markers,Viral Markers,Biochemical Marker,Biologic Marker,Biologic Markers,Clinical Marker,Immune Marker,Immune Markers,Immunologic Marker,Laboratory Marker,Marker, Biochemical,Marker, Biological,Marker, Clinical,Marker, Immunologic,Marker, Laboratory,Marker, Serum,Marker, Surrogate,Serum Marker,Surrogate End Point,Surrogate End Points,Surrogate Endpoint,Surrogate Endpoints,Surrogate Marker,Viral Marker,Biological Marker,End Point, Surrogate,End Points, Surrogate,Endpoint, Surrogate,Endpoints, Surrogate,Marker, Biologic,Marker, Immune,Marker, Viral,Markers, Biologic,Markers, Immune

Related Publications

Tatjana Vilibic-Cavlek, and Ljubo Barbic, and Vladimir Stevanovic, and Goranka Petrovic, and Gordana Mlinaric-Galinovic
Avidity determination of IgG directed against tick-borne encephalitis virus improves detection of current infections.
March 1997, Journal of medical virology,
Tatjana Vilibic-Cavlek, and Ljubo Barbic, and Vladimir Stevanovic, and Goranka Petrovic, and Gordana Mlinaric-Galinovic
The importance of tick-borne encephalitis virus RNA detection for early differential diagnosis of tick-borne encephalitis.
August 2005, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology,
Tatjana Vilibic-Cavlek, and Ljubo Barbic, and Vladimir Stevanovic, and Goranka Petrovic, and Gordana Mlinaric-Galinovic
TICK-BORNE ENCEPHALITIS VIRUS INFECTION IN HUMANS.
January 2016, Medicinski pregled,
Tatjana Vilibic-Cavlek, and Ljubo Barbic, and Vladimir Stevanovic, and Goranka Petrovic, and Gordana Mlinaric-Galinovic
[Infection of macrophages with tick-borne encephalitis virus].
January 2008, Voprosy virusologii,
Tatjana Vilibic-Cavlek, and Ljubo Barbic, and Vladimir Stevanovic, and Goranka Petrovic, and Gordana Mlinaric-Galinovic
Tick-borne encephalitis virus.
May 2022, Journal of medical microbiology,
Tatjana Vilibic-Cavlek, and Ljubo Barbic, and Vladimir Stevanovic, and Goranka Petrovic, and Gordana Mlinaric-Galinovic
Characterization of neutralizing antibodies to Far Eastern of tick-borne encephalitis virus subtype and the antibody avidity for four tick-borne encephalitis vaccines in human.
May 2009, Vaccine,
Tatjana Vilibic-Cavlek, and Ljubo Barbic, and Vladimir Stevanovic, and Goranka Petrovic, and Gordana Mlinaric-Galinovic
[Research on the tick-encephalitis virus. II. Experimental infection of monkeys with the tick-borne encephalitis virus].
January 1954, Przeglad epidemiologiczny,
Tatjana Vilibic-Cavlek, and Ljubo Barbic, and Vladimir Stevanovic, and Goranka Petrovic, and Gordana Mlinaric-Galinovic
Development of an ELISA system for tick-borne encephalitis virus infection in rodents.
February 2011, Microbiology and immunology,
Tatjana Vilibic-Cavlek, and Ljubo Barbic, and Vladimir Stevanovic, and Goranka Petrovic, and Gordana Mlinaric-Galinovic
Diagnosis of tick-borne encephalitis.
April 2003, Vaccine,
Tatjana Vilibic-Cavlek, and Ljubo Barbic, and Vladimir Stevanovic, and Goranka Petrovic, and Gordana Mlinaric-Galinovic
Tick-borne encephalitis virus infection of cultured mouse macrophages.
January 2009, Intervirology,
Copied contents to your clipboard!