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A modified Draize scoring procedure has been used to quantify the vascular effects of prostaglandins on the rabbit eye. Topical application of 100 microgram of PGE1 caused conjunctival redness (erythema due to vasodilatation), swelling (oedema due to increased capillary permeability), discharge, lids closure (decrease in palpebral aperture) and occasionally miosis, though no corneal or iridial damage was detected up to three hours. PGE1 and GE2 produced practically identical dose-related increases in scores for most of the inflammation parameters, though oedema responses were consistently lower after PGE2. The neutral, triethanolamine salt of PGE1 was as inflammatory as PG1 itself. PGF2alpha was 10-50 times less inflammatory than PGE1. It produced relatively greater erythema responses than oedema responses, when compared to PGE1. The novel prostaglandins, 19-OH PGE1 and 19-OH PGE2, recently identified as major prostaglandin constituents of human semen, were respectively 71 and 78 times inflammatory than PGE1. The 19-OH PGEs produced much greater erythema responses, relative to oedema, lids closure or discharge responses.
D W Hall, and
K D Jaitly
February 1980,
Methods and findings in experimental and clinical pharmacology,
D W Hall, and
K D Jaitly
November 1973,
Experimental eye research,
D W Hall, and
K D Jaitly
January 1989,
The American journal of physiology,
D W Hall, and
K D Jaitly
August 1986,
Investigative ophthalmology & visual science,
D W Hall, and
K D Jaitly
January 1975,
The Journal of physiology,
D W Hall, and
K D Jaitly
November 1986,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
D W Hall, and
K D Jaitly
January 1976,
Transactions of the American Ophthalmological Society,
D W Hall, and
K D Jaitly
October 1974,
Canadian journal of physiology and pharmacology,
D W Hall, and
K D Jaitly
January 1967,
Science (New York, N.Y.),
D W Hall, and
K D Jaitly
April 1996,
Klinische Monatsblatter fur Augenheilkunde,
