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One hundred and ninety-one adults with acute myelogenous leukaemia were treated with combination chemotherapy consisting of daunorubicin and cytosine arabinoside (Barts III). Sixty-three patients achieved remission and were admitted to one of 3 trials of active immunotherapy: immunotherapy alone, immunotherapy and maintenance chemotherapy or neither of these. All patients had weekly clinical and blood examination and monthly marrow examination. Reinduction chemotherapy was given as soon as relapse was diagnosed in the marrow. The most striking observation was that immunotherapy was associated with easy and repeated reinduction of remission and marked prolongation of survival after first relapse when compared with immunotherapy plus chemotherapy. The possible reasons for this and the value of immunotherapy are discussed in relation to the third trial still in progress which includes 2 maintenance arms, immunotherapy alone and surveillance only.
R Harris, and
S R Zuhrie, and
C B Freeman, and
G M Taylor, and
J E MacIver, and
C G Geary, and
I W Delamore, and
P J Hull, and
J A Tooth
January 1974,
Johns Hopkins medical journal. Supplement,
R Harris, and
S R Zuhrie, and
C B Freeman, and
G M Taylor, and
J E MacIver, and
C G Geary, and
I W Delamore, and
P J Hull, and
J A Tooth
April 1984,
Lancet (London, England),
R Harris, and
S R Zuhrie, and
C B Freeman, and
G M Taylor, and
J E MacIver, and
C G Geary, and
I W Delamore, and
P J Hull, and
J A Tooth
March 1981,
British medical journal (Clinical research ed.),
R Harris, and
S R Zuhrie, and
C B Freeman, and
G M Taylor, and
J E MacIver, and
C G Geary, and
I W Delamore, and
P J Hull, and
J A Tooth
November 1973,
British journal of cancer,
R Harris, and
S R Zuhrie, and
C B Freeman, and
G M Taylor, and
J E MacIver, and
C G Geary, and
I W Delamore, and
P J Hull, and
J A Tooth
July 1974,
Irish journal of medical science,
R Harris, and
S R Zuhrie, and
C B Freeman, and
G M Taylor, and
J E MacIver, and
C G Geary, and
I W Delamore, and
P J Hull, and
J A Tooth
August 1973,
The British journal of cancer. Supplement,
R Harris, and
S R Zuhrie, and
C B Freeman, and
G M Taylor, and
J E MacIver, and
C G Geary, and
I W Delamore, and
P J Hull, and
J A Tooth
July 1980,
British journal of haematology,
R Harris, and
S R Zuhrie, and
C B Freeman, and
G M Taylor, and
J E MacIver, and
C G Geary, and
I W Delamore, and
P J Hull, and
J A Tooth
June 1969,
British medical journal,
R Harris, and
S R Zuhrie, and
C B Freeman, and
G M Taylor, and
J E MacIver, and
C G Geary, and
I W Delamore, and
P J Hull, and
J A Tooth
September 1977,
British journal of haematology,
R Harris, and
S R Zuhrie, and
C B Freeman, and
G M Taylor, and
J E MacIver, and
C G Geary, and
I W Delamore, and
P J Hull, and
J A Tooth
February 1977,
British journal of haematology,
