Regional Lung Ventilation Analysis Using Temporally Resolved Magnetic Resonance Imaging. 2016

Christoph Kolb, and Andreas Wetscherek, and Maria Teodora Buzan, and René Werner, and Christopher M Rank, and Marc Kachelrie, and Michael Kreuter, and Julien Dinkel, and Claus Peter Heuel, and Klaus Maier-Hein
From the *Junior Group Medical Image Computing and †Division of Medical Physics in Radiology, DKFZ, Heidelberg, Germany; ‡Joint Department of Physics at the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, London, United Kingdom; §Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at Heidelberg University, Heidelberg, Germany; ∥Department of Pneumology, luliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; ¶Department of Diagnostic and of Interventional Radiology Heidelberg University, Heidelberg; #Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg; **Department of Pneumology and Respiratory Critical Care Medicine, Thoraxklinik at Heidelberg University Hospital; ††Translational Lung Research Center Heidelberg (TLRC-H), member of the German Center for Lung Research (DZL), Heidelberg; ‡‡Institute of Clinical Radiology, Munich; §§Comprehensive Pneumology Center Munich (CPC-M), member of the German Center for Lung Research (DZL); and ∥∥Division of Radiology, DKFZ, Heidelberg, Germany.

OBJECTIVE We propose a computer-aided method for regional ventilation analysis and observation of lung diseases in temporally resolved magnetic resonance imaging (4D MRI). METHODS A shape model-based segmentation and registration workflow was used to create an atlas-derived reference system in which regional tissue motion can be quantified and multimodal image data can be compared regionally. Model-based temporal registration of the lung surfaces in 4D MRI data was compared with the registration of 4D computed tomography (CT) images. A ventilation analysis was performed on 4D MR images of patients with lung fibrosis; 4D MR ventilation maps were compared with corresponding diagnostic 3D CT images of the patients and 4D CT maps of subjects without impaired lung function (serving as reference). RESULTS Comparison between the computed patient-specific 4D MR regional ventilation maps and diagnostic CT images shows good correlation in conspicuous regions. Comparison to 4D CT-derived ventilation maps supports the plausibility of the 4D MR maps. Dynamic MRI-based flow-volume loops and spirograms further visualize the free-breathing behavior. CONCLUSIONS The proposed methods allow for 4D MR-based regional analysis of tissue dynamics and ventilation in spontaneous breathing and comparison of patient data. The proposed atlas-based reference coordinate system provides an automated manner of annotating and comparing multimodal lung image data.

UI MeSH Term Description Entries
D007089 Image Enhancement Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level. Image Quality Enhancement,Enhancement, Image,Enhancement, Image Quality,Enhancements, Image,Enhancements, Image Quality,Image Enhancements,Image Quality Enhancements,Quality Enhancement, Image,Quality Enhancements, Image
D007090 Image Interpretation, Computer-Assisted Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease. Image Interpretation, Computer Assisted,Computer-Assisted Image Interpretation,Computer-Assisted Image Interpretations,Image Interpretations, Computer-Assisted,Interpretation, Computer-Assisted Image,Interpretations, Computer-Assisted Image
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D011658 Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. Alveolitis, Fibrosing,Idiopathic Diffuse Interstitial Pulmonary Fibrosis,Fibroses, Pulmonary,Fibrosis, Pulmonary,Pulmonary Fibroses,Alveolitides, Fibrosing,Fibrosing Alveolitides,Fibrosing Alveolitis
D012123 Pulmonary Ventilation The total volume of gas inspired or expired per unit of time, usually measured in liters per minute. Respiratory Airflow,Ventilation Tests,Ventilation, Pulmonary,Expiratory Airflow,Airflow, Expiratory,Airflow, Respiratory,Test, Ventilation,Tests, Ventilation,Ventilation Test
D003198 Computer Simulation Computer-based representation of physical systems and phenomena such as chemical processes. Computational Modeling,Computational Modelling,Computer Models,In silico Modeling,In silico Models,In silico Simulation,Models, Computer,Computerized Models,Computer Model,Computer Simulations,Computerized Model,In silico Model,Model, Computer,Model, Computerized,Model, In silico,Modeling, Computational,Modeling, In silico,Modelling, Computational,Simulation, Computer,Simulation, In silico,Simulations, Computer
D005260 Female Females

Related Publications

Christoph Kolb, and Andreas Wetscherek, and Maria Teodora Buzan, and René Werner, and Christopher M Rank, and Marc Kachelrie, and Michael Kreuter, and Julien Dinkel, and Claus Peter Heuel, and Klaus Maier-Hein
March 2019, Academic radiology,
Christoph Kolb, and Andreas Wetscherek, and Maria Teodora Buzan, and René Werner, and Christopher M Rank, and Marc Kachelrie, and Michael Kreuter, and Julien Dinkel, and Claus Peter Heuel, and Klaus Maier-Hein
November 2012, Magnetic resonance in medicine,
Christoph Kolb, and Andreas Wetscherek, and Maria Teodora Buzan, and René Werner, and Christopher M Rank, and Marc Kachelrie, and Michael Kreuter, and Julien Dinkel, and Claus Peter Heuel, and Klaus Maier-Hein
November 1996, Nature medicine,
Christoph Kolb, and Andreas Wetscherek, and Maria Teodora Buzan, and René Werner, and Christopher M Rank, and Marc Kachelrie, and Michael Kreuter, and Julien Dinkel, and Claus Peter Heuel, and Klaus Maier-Hein
November 2018, The European respiratory journal,
Christoph Kolb, and Andreas Wetscherek, and Maria Teodora Buzan, and René Werner, and Christopher M Rank, and Marc Kachelrie, and Michael Kreuter, and Julien Dinkel, and Claus Peter Heuel, and Klaus Maier-Hein
May 2023, Pediatric radiology,
Christoph Kolb, and Andreas Wetscherek, and Maria Teodora Buzan, and René Werner, and Christopher M Rank, and Marc Kachelrie, and Michael Kreuter, and Julien Dinkel, and Claus Peter Heuel, and Klaus Maier-Hein
March 2001, European journal of radiology,
Christoph Kolb, and Andreas Wetscherek, and Maria Teodora Buzan, and René Werner, and Christopher M Rank, and Marc Kachelrie, and Michael Kreuter, and Julien Dinkel, and Claus Peter Heuel, and Klaus Maier-Hein
January 2012, Polish journal of radiology,
Christoph Kolb, and Andreas Wetscherek, and Maria Teodora Buzan, and René Werner, and Christopher M Rank, and Marc Kachelrie, and Michael Kreuter, and Julien Dinkel, and Claus Peter Heuel, and Klaus Maier-Hein
June 2016, Magnetic resonance in chemistry : MRC,
Christoph Kolb, and Andreas Wetscherek, and Maria Teodora Buzan, and René Werner, and Christopher M Rank, and Marc Kachelrie, and Michael Kreuter, and Julien Dinkel, and Claus Peter Heuel, and Klaus Maier-Hein
July 2000, Magnetic resonance in medicine,
Christoph Kolb, and Andreas Wetscherek, and Maria Teodora Buzan, and René Werner, and Christopher M Rank, and Marc Kachelrie, and Michael Kreuter, and Julien Dinkel, and Claus Peter Heuel, and Klaus Maier-Hein
January 1985, Magnetic resonance imaging,
Copied contents to your clipboard!