Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. 1989

K Lyons, and J L Graycar, and A Lee, and S Hashmi, and P B Lindquist, and E Y Chen, and B L Hogan, and R Derynck
Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.

The transforming growth factor beta (TGF-beta)-related products of the Xenopus Vg-1 and Drosophila decapentaplegic (DPP) genes have been implicated in the control of growth and differentiation during embryogenesis. We have isolated a mouse cDNA, Vgr-1, that encodes a polypeptide structurally related to Xenopus Vg-1. Sequence comparisons indicate that the Vgr-1 protein belongs to a family of DPP-like gene products within the TGF-beta superfamily. The levels of Vgr-1 RNA were determined in embryos and tissues isolated at various stages of development. A 3.5-kilobase mRNA increases throughout development and into adulthood in many tissues and in F9 teratocarcinoma cells differentiating into endoderm in response to retinoic acid and cAMP. The amino acid homologies and patterns of expression suggest that, like the DPP gene product, Vgr-1 plays a role at various stages of development.

UI MeSH Term Description Entries
D008813 Mice, Inbred ICR An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER. Mice, Inbred ICRC,Mice, ICR,Mouse, ICR,Mouse, Inbred ICR,Mouse, Inbred ICRC,ICR Mice,ICR Mice, Inbred,ICR Mouse,ICR Mouse, Inbred,ICRC Mice, Inbred,ICRC Mouse, Inbred,Inbred ICR Mice,Inbred ICR Mouse,Inbred ICRC Mice,Inbred ICRC Mouse
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009928 Organ Specificity Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen. Tissue Specificity,Organ Specificities,Specificities, Organ,Specificities, Tissue,Specificity, Organ,Specificity, Tissue,Tissue Specificities
D004330 Drosophila A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology. Fruit Fly, Drosophila,Drosophila Fruit Flies,Drosophila Fruit Fly,Drosophilas,Flies, Drosophila Fruit,Fly, Drosophila Fruit,Fruit Flies, Drosophila
D005796 Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. Cistron,Gene,Genetic Materials,Cistrons,Genetic Material,Material, Genetic,Materials, Genetic
D005810 Multigene Family A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed) Gene Clusters,Genes, Reiterated,Cluster, Gene,Clusters, Gene,Families, Multigene,Family, Multigene,Gene Cluster,Gene, Reiterated,Multigene Families,Reiterated Gene,Reiterated Genes
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA

Related Publications

K Lyons, and J L Graycar, and A Lee, and S Hashmi, and P B Lindquist, and E Y Chen, and B L Hogan, and R Derynck
November 1992, Molecular endocrinology (Baltimore, Md.),
K Lyons, and J L Graycar, and A Lee, and S Hashmi, and P B Lindquist, and E Y Chen, and B L Hogan, and R Derynck
July 1990, Molecular endocrinology (Baltimore, Md.),
K Lyons, and J L Graycar, and A Lee, and S Hashmi, and P B Lindquist, and E Y Chen, and B L Hogan, and R Derynck
February 2004, The Journal of biological chemistry,
K Lyons, and J L Graycar, and A Lee, and S Hashmi, and P B Lindquist, and E Y Chen, and B L Hogan, and R Derynck
January 1995, Growth factors (Chur, Switzerland),
K Lyons, and J L Graycar, and A Lee, and S Hashmi, and P B Lindquist, and E Y Chen, and B L Hogan, and R Derynck
December 2002, Endocrine reviews,
K Lyons, and J L Graycar, and A Lee, and S Hashmi, and P B Lindquist, and E Y Chen, and B L Hogan, and R Derynck
July 1996, Biochimica et biophysica acta,
K Lyons, and J L Graycar, and A Lee, and S Hashmi, and P B Lindquist, and E Y Chen, and B L Hogan, and R Derynck
January 1995, Trends in endocrinology and metabolism: TEM,
K Lyons, and J L Graycar, and A Lee, and S Hashmi, and P B Lindquist, and E Y Chen, and B L Hogan, and R Derynck
May 1998, Biochemical and biophysical research communications,
K Lyons, and J L Graycar, and A Lee, and S Hashmi, and P B Lindquist, and E Y Chen, and B L Hogan, and R Derynck
May 2000, Molecular and cellular biology,
K Lyons, and J L Graycar, and A Lee, and S Hashmi, and P B Lindquist, and E Y Chen, and B L Hogan, and R Derynck
January 2000, Proceedings of the National Academy of Sciences of the United States of America,
Copied contents to your clipboard!