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Serum levels of CA 19-9, CA 125 and CA 15-3 were measured in 91 patients with cervical cancer (16 with intraepithelial neoplasia and 75 with invasive cancer). In 35 patients with locally advanced cervical cancer, serum marker levels were measured at monthly intervals during neo-adjuvant chemotherapy. CA 19-9 was found to be abnormally high only in advanced stages with an overall sensitivity of 7.3%. CA 125 and CA 15-3 were elevated in 31.9 and 23.1% of the patients, respectively, with a combined sensitivity of about 40%. The mean values of CA 125 and CA 15-3 were positively related to clinical stage and tumor differentiation. CA 125 and CA 15-3 values were correlated with response to chemotherapy in more than 80% of the cases. These findings suggest that CA 125 and CA 15-3 could be usefully employed in the management of cervical cancer.
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C Sonsini, and
S Greggi, and
F Battaglia, and
S Mancuso
December 1989,
Hematology/oncology clinics of North America,
P Benedetti Panici, and
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C Sonsini, and
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January 1990,
Anticancer research,
P Benedetti Panici, and
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January 1996,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
P Benedetti Panici, and
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C Sonsini, and
S Greggi, and
F Battaglia, and
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January 1993,
Pathologie-biologie,
P Benedetti Panici, and
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S Greggi, and
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December 2020,
Journal of immunotoxicology,
P Benedetti Panici, and
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January 1992,
Anticancer research,
P Benedetti Panici, and
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F Battaglia, and
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November 2012,
Clinical cancer research : an official journal of the American Association for Cancer Research,
P Benedetti Panici, and
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April 2024,
Molecular aspects of medicine,
P Benedetti Panici, and
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F Battaglia, and
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December 2002,
Journal of biochemistry, molecular biology, and biophysics : JBMBB : the official journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB),
P Benedetti Panici, and
G Scambia, and
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January 2019,
Cancer management and research,
