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Zinc deficiency is a significant clinical finding in sickle cell anemia (SCA) and abnormalities of zinc handling such as hyperzincuria are present. The cause of increased urinary zinc excretion in SCA is not clear. To define the renal handling of zinc in SCA and in healthy subjects, we measured zinc (total and ultrafilterable plasma zinc, urine zinc) and creatinine clearance in eight healthy and seven SCA subjects. Ultrafilterable zinc in plasma was assessed by equilibration of plasma with 65Zn followed by filtration through Amicon Cetriflo CF25 cones. While the mean filtered load of zinc was not significantly different between the two groups, the mean zinc excretion rate was approximately three-fold higher in patients (1.73 +/- 0.96 vs. 0.63 +/- 0.39 micrograms/min, P less than .05). In controls, zinc excreted was significantly less than zinc filtered (P less than .005), the fractional excretion of zinc averaging 0.49 +/- 0.31, indicating net reabsorption. This was not the case for the SCA patients. We conclude that there is impaired renal tubular handling of zinc in SCA.
V A Yuzbasiyan-Gurkan, and
G J Brewer, and
A J Vander, and
M J Guenther, and
A S Prasad
March 1975,
The Journal of laboratory and clinical medicine,
V A Yuzbasiyan-Gurkan, and
G J Brewer, and
A J Vander, and
M J Guenther, and
A S Prasad
January 1999,
American journal of nephrology,
V A Yuzbasiyan-Gurkan, and
G J Brewer, and
A J Vander, and
M J Guenther, and
A S Prasad
January 2018,
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia,
V A Yuzbasiyan-Gurkan, and
G J Brewer, and
A J Vander, and
M J Guenther, and
A S Prasad
January 1974,
Advances in experimental medicine and biology,
V A Yuzbasiyan-Gurkan, and
G J Brewer, and
A J Vander, and
M J Guenther, and
A S Prasad
April 1970,
The Journal of laboratory and clinical medicine,
V A Yuzbasiyan-Gurkan, and
G J Brewer, and
A J Vander, and
M J Guenther, and
A S Prasad
March 1979,
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V A Yuzbasiyan-Gurkan, and
G J Brewer, and
A J Vander, and
M J Guenther, and
A S Prasad
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V A Yuzbasiyan-Gurkan, and
G J Brewer, and
A J Vander, and
M J Guenther, and
A S Prasad
January 1986,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
V A Yuzbasiyan-Gurkan, and
G J Brewer, and
A J Vander, and
M J Guenther, and
A S Prasad
September 1968,
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V A Yuzbasiyan-Gurkan, and
G J Brewer, and
A J Vander, and
M J Guenther, and
A S Prasad
July 1975,
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