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Metal-Free Synthesis of Fully Substituted Pyridines via Ring Construction Based on the Domino Reactions of Enaminones and Aldehydes. 2016

Jie-Ping Wan, and Yanfeng Jing, and Changfeng Hu, and Shouri Sheng
College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang 330022, P. R. China.

An unprecedented domino reaction involving primary enaminones/enaminoesters and aldehydes has been developed for the synthesis of fully substituted pyridines. The construction of the products has been accomplished via the cascade generation of two C-C and one C-N bond by simply using TfOH as a promoter.

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