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The role of human growth hormone (hGH) on placental hormone secretion at term was investigated in two in vitro models: placental explants and cultured trophoblastic cells. Physiological concentrations of hGH caused a significant dose-dependent increase in placental lactogen and progesterone secretion. In the explant model it stimulated estradiol secretion. In order to determine whether this stimulatory effect on estradiol is exerted via aromatase, an isolated cell culture was utilized where androstenedione was supplied as substrate. In this model, hGH exerted a mild inhibitory effect. In conclusion, hGH at levels present in the fetal circulation exerts a significant stimulatory effect upon placental function as reflected by both peptide and steroid hormone production and secretion. The effect of estradiol secretion is the end result of an inhibitory effect on androgen aromatization and a stimulatory effect on earlier steps.
E R Barnea, and
R Perlman, and
T Bick, and
Z Hochberg
January 1993,
Human reproduction (Oxford, England),
E R Barnea, and
R Perlman, and
T Bick, and
Z Hochberg
September 1987,
The Journal of endocrinology,
E R Barnea, and
R Perlman, and
T Bick, and
Z Hochberg
January 1969,
Endocrinology,
E R Barnea, and
R Perlman, and
T Bick, and
Z Hochberg
September 1988,
The Journal of clinical investigation,
E R Barnea, and
R Perlman, and
T Bick, and
Z Hochberg
June 1992,
Anales espanoles de pediatria,
E R Barnea, and
R Perlman, and
T Bick, and
Z Hochberg
December 1997,
American journal of obstetrics and gynecology,
E R Barnea, and
R Perlman, and
T Bick, and
Z Hochberg
May 1989,
Nucleic acids research,
E R Barnea, and
R Perlman, and
T Bick, and
Z Hochberg
November 1991,
Neuroendocrinology,
E R Barnea, and
R Perlman, and
T Bick, and
Z Hochberg
May 1993,
The Journal of endocrinology,
E R Barnea, and
R Perlman, and
T Bick, and
Z Hochberg
April 1995,
Endocrine,
