BIOMAT Database Logo BIOMAT Database Logo

Studies on DNA interaction of organotin(IV) complexes of meso-tetra(4-sulfonatophenyl)porphine that show cellular activity. 2016

Sabriye Aydinoglu, and Tarita Biver, and Stefania Figuccia, and Tiziana Fiore, and Sonia Montanaro, and Claudia Pellerito
Department of Analytical Chemistry, Faculty of Pharmacy, Cukurova University, 01330 Adana, Turkey.

The interaction of the diorgano- and triorganotin(IV) derivatives of meso-tetra-(4-sulfonatophenyl)porphine (Me2Sn)2TPPS, (Bu2Sn)2TPPS, (Me3Sn)4TPPS and (Bu3Sn)4TPPS to natural DNA was analysed (together with free meso-tetra-(4-sulfonatophenyl)porphine (TPPS4-) for comparison purposes). Particular attention was paid to (Bu3Sn)4TPPS, a species that shows significant cellular action. Preliminary tests were done on the solution properties of the organotin(IV) compounds (pKA and possible self-aggregation). Spectrophotometric and spectrofluorometric experiments showed that all the investigated organotin(IV) derivatives strongly interact with DNA, the binding energy depending on the dye steric hindrance. In all cases experimental data concur in indicating that external binding mode prevails. Interestingly, fluorescence quenching and viscosity experiments show that the Bu-containing species, and in particular (Bu3Sn)4TPPS, are able to noticeably alter the DNA conformation.

UI MeSH Term Description Entries
D009690 Nucleic Acid Conformation The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape. DNA Conformation,RNA Conformation,Conformation, DNA,Conformation, Nucleic Acid,Conformation, RNA,Conformations, DNA,Conformations, Nucleic Acid,Conformations, RNA,DNA Conformations,Nucleic Acid Conformations,RNA Conformations
D009947 Organotin Compounds Organic compounds which contain tin in the molecule. Used widely in industry and agriculture. Compounds, Organotin
D011166 Porphyrins A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin. Porphyrin
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000072283 A549 Cells An immortalized cell line derived from human ADENOCARCINOMA, ALVEOLAR basal epithelial cells isolated from the lungs of a male patient in 1972. The cell line is positive for KERATIN, can synthesize LECITHIN, and contains high levels of POLYUNSATURATED FATTY ACIDS in its PLASMA MEMBRANE. It is used as a model for PULMONARY ALVEOLI function and virus infections, as a TRANSFECTION host, and for PRECLINICAL DRUG EVALUATION. A549 Cell Line,A549 Cell,A549 Cell Lines,Cell Line, A549,Cell Lines, A549,Cell, A549,Cells, A549

Related Publications

Sabriye Aydinoglu, and Tarita Biver, and Stefania Figuccia, and Tiziana Fiore, and Sonia Montanaro, and Claudia Pellerito
Meso-tetra-(4-sulfonatophenyl)-porphine of low neurotoxicity.
January 1995, Sbornik lekarsky,
Sabriye Aydinoglu, and Tarita Biver, and Stefania Figuccia, and Tiziana Fiore, and Sonia Montanaro, and Claudia Pellerito
Diorganotin(IV) and triorganotin(IV) complexes of meso-tetra(4-sulfonatophenyl)porphine induce apoptosis in A375 human melanoma cells.
July 2006, Cancer letters,
Sabriye Aydinoglu, and Tarita Biver, and Stefania Figuccia, and Tiziana Fiore, and Sonia Montanaro, and Claudia Pellerito
Supramolecular assemblies based on complexes of nonionic amphiphilic cyclodextrins and a meso-tetra(4-sulfonatophenyl)porphine tributyltin(IV) derivative: potential nanotherapeutics against melanoma.
November 2013, Biomacromolecules,
Sabriye Aydinoglu, and Tarita Biver, and Stefania Figuccia, and Tiziana Fiore, and Sonia Montanaro, and Claudia Pellerito
Photoresponsive Porphyrin Nanotubes of Meso-tetra(4-Sulfonatophenyl)Porphyrin and Sn(IV) meso-tetra(4-pyridyl)porphyrin.
January 2019, Frontiers in chemistry,
Sabriye Aydinoglu, and Tarita Biver, and Stefania Figuccia, and Tiziana Fiore, and Sonia Montanaro, and Claudia Pellerito
Binding of meso-tetra(4-sulfonatophenyl)porphine to haemopexin and albumin studied by spectroscopy methods.
May 1994, The International journal of biochemistry,
Sabriye Aydinoglu, and Tarita Biver, and Stefania Figuccia, and Tiziana Fiore, and Sonia Montanaro, and Claudia Pellerito
Apoptosis and cell growth arrest in A375 human melanoma cells by diorganotin(IV) and triorganotin(IV) complexes of [meso-Tetra(4-sulfonatophenyl)porphine] manganese(III)chloride.
March 2011, International journal of oncology,
Sabriye Aydinoglu, and Tarita Biver, and Stefania Figuccia, and Tiziana Fiore, and Sonia Montanaro, and Claudia Pellerito
Dibutyltin(IV) and Tributyltin(IV) Derivatives of meso-Tetra(4-sulfonatophenyl)porphine Inhibit the Growth and the Migration of Human Melanoma Cells.
November 2019, Cells,
Sabriye Aydinoglu, and Tarita Biver, and Stefania Figuccia, and Tiziana Fiore, and Sonia Montanaro, and Claudia Pellerito
Binding of meso-tetra (4-N-methylpyridyl) porphine to DNA.
June 1980, Nucleic acids research,
Sabriye Aydinoglu, and Tarita Biver, and Stefania Figuccia, and Tiziana Fiore, and Sonia Montanaro, and Claudia Pellerito
Novel Organotin(IV)-Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Activity, and DNA Interaction Studies.
January 2010, Bioinorganic chemistry and applications,
Sabriye Aydinoglu, and Tarita Biver, and Stefania Figuccia, and Tiziana Fiore, and Sonia Montanaro, and Claudia Pellerito
Photodynamic effects of meso-tetra (4-sulfonatophenyl)porphine on human leukemia cells HEL and HL60, human lymphocytes and bone marrow progenitor cells.
July 1997, Journal of photochemistry and photobiology. B, Biology,
Copied contents to your clipboard!