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The COUP (chicken ovalbumin upstream promoter) transcription factor (COUP-TF) exists in a number of different tissues and is essential for expression of the chicken ovalbumin gene. It binds to the ovalbumin promoter and, in conjunction with a second protein (S300-II), stimulates initiation of transcription in vitro. COUP-TF also binds specifically to the rat insulin promoter element, although the two binding sites share little sequence similarity. Here we report the isolation of a human complementary DNA clone encoding COUP-TF. Comparison of the amino-acid sequence of COUP-TF with known sequences reveals that it is a member of the steroid/thyroid hormone/vitamin receptor superfamily. Consequently, it is the first member of this family that has been shown to function in a cell-free transcription system. We conclude that this superfamily of gene regulators contains proteins which bind and activate distal promoter elements of eukaryotic genes.
L H Wang, and
S Y Tsai, and
R G Cook, and
W G Beattie, and
M J Tsai, and
B W O'Malley
August 1994,
Trends in endocrinology and metabolism: TEM,
L H Wang, and
S Y Tsai, and
R G Cook, and
W G Beattie, and
M J Tsai, and
B W O'Malley
December 1990,
Genes & development,
L H Wang, and
S Y Tsai, and
R G Cook, and
W G Beattie, and
M J Tsai, and
B W O'Malley
December 1988,
Nature,
L H Wang, and
S Y Tsai, and
R G Cook, and
W G Beattie, and
M J Tsai, and
B W O'Malley
January 1991,
Receptor,
L H Wang, and
S Y Tsai, and
R G Cook, and
W G Beattie, and
M J Tsai, and
B W O'Malley
June 1991,
Molecular endocrinology (Baltimore, Md.),
L H Wang, and
S Y Tsai, and
R G Cook, and
W G Beattie, and
M J Tsai, and
B W O'Malley
April 1993,
The Journal of biological chemistry,
L H Wang, and
S Y Tsai, and
R G Cook, and
W G Beattie, and
M J Tsai, and
B W O'Malley
January 1989,
Journal of steroid biochemistry,
L H Wang, and
S Y Tsai, and
R G Cook, and
W G Beattie, and
M J Tsai, and
B W O'Malley
January 1996,
Cancer detection and prevention,
L H Wang, and
S Y Tsai, and
R G Cook, and
W G Beattie, and
M J Tsai, and
B W O'Malley
July 1990,
Cell,
L H Wang, and
S Y Tsai, and
R G Cook, and
W G Beattie, and
M J Tsai, and
B W O'Malley
October 1990,
Nature,
