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BACKGROUND Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. OBJECTIVE To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. METHODS Twelve patients with well controlled asthma were studied. On the first day, after determining the initial values of pulmonary function, a dose response curve was carried out with progressive doses of methacholine. After the last dose, when at least a 20% drop of the initial forced expiratory volume in the first second (FEV1) was achieved, vital capacity (VC) and FEV1 were measured at 7, 15 and 30 minutes after provocation. On the second day a diazepam aerosol was inhaled by the patients prior to the same protocol with methacholine. RESULTS In the first day of testing, methacholine inhalation (6 mg/mL) led to a significant drop in FEV1 from 2.98 to 1.69 L. On the second day of study, in the same patients, previous inhalation with diazepam reduced the changes of FEV1 after inhalation of methacholine. This parameter decreased from 2.48 to 2.21 L. CONCLUSIONS Inhalation of benzodiazepines reduce bronchoconstriction after a methacholine challenge in patients with asthma.
Mirjana Miric, and
Sinisa Ristic, and
Bojan N Joksimovic, and
Snezana Medenica, and
Maja Racic, and
Slavica Ristic, and
Vedrana R Joksimovic, and
Mirjana Skipina
August 1994,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
Mirjana Miric, and
Sinisa Ristic, and
Bojan N Joksimovic, and
Snezana Medenica, and
Maja Racic, and
Slavica Ristic, and
Vedrana R Joksimovic, and
Mirjana Skipina
June 1990,
The European respiratory journal,
Mirjana Miric, and
Sinisa Ristic, and
Bojan N Joksimovic, and
Snezana Medenica, and
Maja Racic, and
Slavica Ristic, and
Vedrana R Joksimovic, and
Mirjana Skipina
April 2000,
The European respiratory journal,
Mirjana Miric, and
Sinisa Ristic, and
Bojan N Joksimovic, and
Snezana Medenica, and
Maja Racic, and
Slavica Ristic, and
Vedrana R Joksimovic, and
Mirjana Skipina
March 2018,
Allergy, asthma & immunology research,
Mirjana Miric, and
Sinisa Ristic, and
Bojan N Joksimovic, and
Snezana Medenica, and
Maja Racic, and
Slavica Ristic, and
Vedrana R Joksimovic, and
Mirjana Skipina
May 1992,
The European respiratory journal,
Mirjana Miric, and
Sinisa Ristic, and
Bojan N Joksimovic, and
Snezana Medenica, and
Maja Racic, and
Slavica Ristic, and
Vedrana R Joksimovic, and
Mirjana Skipina
February 1987,
The Journal of allergy and clinical immunology,
Mirjana Miric, and
Sinisa Ristic, and
Bojan N Joksimovic, and
Snezana Medenica, and
Maja Racic, and
Slavica Ristic, and
Vedrana R Joksimovic, and
Mirjana Skipina
July 1991,
Chest,
Mirjana Miric, and
Sinisa Ristic, and
Bojan N Joksimovic, and
Snezana Medenica, and
Maja Racic, and
Slavica Ristic, and
Vedrana R Joksimovic, and
Mirjana Skipina
July 1993,
The New England journal of medicine,
Mirjana Miric, and
Sinisa Ristic, and
Bojan N Joksimovic, and
Snezana Medenica, and
Maja Racic, and
Slavica Ristic, and
Vedrana R Joksimovic, and
Mirjana Skipina
June 2000,
Pediatric pulmonology,
Mirjana Miric, and
Sinisa Ristic, and
Bojan N Joksimovic, and
Snezana Medenica, and
Maja Racic, and
Slavica Ristic, and
Vedrana R Joksimovic, and
Mirjana Skipina
September 2000,
International journal of clinical pharmacology and therapeutics,
