BIOMAT Database Logo BIOMAT Database Logo

Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016. 2016

Basil Britto Xavier, and Christine Lammens, and Rohit Ruhal, and Samir Kumar-Singh, and Patrick Butaye, and Herman Goossens, and Surbhi Malhotra-Kumar
Laboratory of Medical Microbiology, Wilrijk, Belgium.

We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.

UI MeSH Term Description Entries
D010957 Plasmids Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS. Episomes,Episome,Plasmid
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D003091 Colistin Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally. Polymyxin E,Colimycin,Colisticin,Colistin Sulfate,Coly-Mycin,Totazina,Sulfate, Colistin
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004926 Escherichia coli A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc. Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001426 Bacterial Proteins Proteins found in any species of bacterium. Bacterial Gene Products,Bacterial Gene Proteins,Gene Products, Bacterial,Bacterial Gene Product,Bacterial Gene Protein,Bacterial Protein,Gene Product, Bacterial,Gene Protein, Bacterial,Gene Proteins, Bacterial,Protein, Bacterial,Proteins, Bacterial
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D024881 Drug Resistance, Bacterial The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS). Antibiotic Resistance, Bacterial,Antibacterial Drug Resistance

Related Publications

Basil Britto Xavier, and Christine Lammens, and Rohit Ruhal, and Samir Kumar-Singh, and Patrick Butaye, and Herman Goossens, and Surbhi Malhotra-Kumar
Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli.
June 2017, mBio,
Basil Britto Xavier, and Christine Lammens, and Rohit Ruhal, and Samir Kumar-Singh, and Patrick Butaye, and Herman Goossens, and Surbhi Malhotra-Kumar
Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016.
August 2017, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,
Basil Britto Xavier, and Christine Lammens, and Rohit Ruhal, and Samir Kumar-Singh, and Patrick Butaye, and Herman Goossens, and Surbhi Malhotra-Kumar
Erratum for Yin et al., "Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli".
August 2017, mBio,
Basil Britto Xavier, and Christine Lammens, and Rohit Ruhal, and Samir Kumar-Singh, and Patrick Butaye, and Herman Goossens, and Surbhi Malhotra-Kumar
ISEc69-Mediated Mobilization of the Colistin Resistance Gene mcr-2 in Escherichia coli.
January 2020, Frontiers in microbiology,
Basil Britto Xavier, and Christine Lammens, and Rohit Ruhal, and Samir Kumar-Singh, and Patrick Butaye, and Herman Goossens, and Surbhi Malhotra-Kumar
Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae.
July 2018, The Journal of antimicrobial chemotherapy,
Basil Britto Xavier, and Christine Lammens, and Rohit Ruhal, and Samir Kumar-Singh, and Patrick Butaye, and Herman Goossens, and Surbhi Malhotra-Kumar
Emergence of Plasmid-Mediated Colistin Resistance Gene mcr-1 in a Clinical Escherichia coli Isolate from Egypt.
May 2016, Antimicrobial agents and chemotherapy,
Basil Britto Xavier, and Christine Lammens, and Rohit Ruhal, and Samir Kumar-Singh, and Patrick Butaye, and Herman Goossens, and Surbhi Malhotra-Kumar
Identification of the Plasmid-Mediated Colistin Resistance Gene mcr-1 in Escherichia coli Isolates From Migratory Birds in Guangdong, China.
January 2021, Frontiers in microbiology,
Basil Britto Xavier, and Christine Lammens, and Rohit Ruhal, and Samir Kumar-Singh, and Patrick Butaye, and Herman Goossens, and Surbhi Malhotra-Kumar
Acquisition of Plasmid-Mediated Colistin Resistance Gene mcr-1 in Escherichia coli of Livestock Origin in Bangladesh.
September 2020, Microbial drug resistance (Larchmont, N.Y.),
Basil Britto Xavier, and Christine Lammens, and Rohit Ruhal, and Samir Kumar-Singh, and Patrick Butaye, and Herman Goossens, and Surbhi Malhotra-Kumar
Plasmid-Mediated mcr-1 Colistin Resistance in Escherichia coli from a Black Kite in Russia.
September 2019, Antimicrobial agents and chemotherapy,
Basil Britto Xavier, and Christine Lammens, and Rohit Ruhal, and Samir Kumar-Singh, and Patrick Butaye, and Herman Goossens, and Surbhi Malhotra-Kumar
Plasmid-mediated colistin resistance gene mcr-1 in a clinical Escherichia coli isolate in the Indian Ocean Commission.
September 2018, Medecine et maladies infectieuses,
Copied contents to your clipboard!