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We report the results of a simulation study designed to assess the capability of segregation analysis to detect Mendelian transmission and to estimate genetic model parameters for complex qualitative traits, characterized by heritability in the range 0.20-0.45 and low heterozygote penetrance. The pedigree analysis package, PAP, was used to perform the analyses. For all data sets, models of no transmission could be rejected. In most cases, models of Mendelian transmission could not be rejected; however, several samples approached significance levels. When Mendelian transmission was assumed, reasonably good parameter estimates were obtained, although heterozygote penetrances were often overestimated. Different sampling schemes were imposed on the simulated data in order to examine the extent of information loss with the reduction in sample size. One of these strategies (a sequential sampling scheme) appears to have resulted in critical loss of information in some cases.
P L Kramer, and
D L Pauls, and
R A Price, and
K K Kidd
November 1982,
American journal of human genetics,
P L Kramer, and
D L Pauls, and
R A Price, and
K K Kidd
January 2001,
Genetic epidemiology,
P L Kramer, and
D L Pauls, and
R A Price, and
K K Kidd
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Progress in clinical and biological research,
P L Kramer, and
D L Pauls, and
R A Price, and
K K Kidd
January 1987,
Genetic epidemiology,
P L Kramer, and
D L Pauls, and
R A Price, and
K K Kidd
January 1977,
American journal of medical genetics,
P L Kramer, and
D L Pauls, and
R A Price, and
K K Kidd
January 1985,
Human heredity,
P L Kramer, and
D L Pauls, and
R A Price, and
K K Kidd
May 2003,
Theoretical population biology,
P L Kramer, and
D L Pauls, and
R A Price, and
K K Kidd
January 1979,
Human heredity,
P L Kramer, and
D L Pauls, and
R A Price, and
K K Kidd
August 1964,
Heredity,
P L Kramer, and
D L Pauls, and
R A Price, and
K K Kidd
June 1984,
Biometrics,
