Biomaterial Database

Age-related decreases in cardiac receptor control of forearm vascular resistance in humans. 1989

S Jingu, and A Takeshita, and T Imaizumi, and K Sakai, and M Nakamura

Research Institute of Angiocardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

We examined 1) the relationship between the magnitudes of reflex forearm vasoconstriction during lower body negative pressure (LBNP) at -10 mmHg and ages in 59 subjects whose ages ranged from 24 to 77 years old, and 2) the slopes of the regression lines relating changes in forearm vascular resistance and those in central venous pressure in the three age-groups; those younger than 35 years old (n = 15), those between 35 and 55 years old (n = 12) and those older than 55 years old (n = 12). Forearm blood flow was measured using a strain gauge plethysmograph and forearm vascular resistance was calculated from forearm blood flow and mean blood pressure. There was a significant negative correlation (r = -0.512, p less than 0.01) between age and the magnitude of reflex forearm vasoconstriction during LBNP at -10 mmHg. The slope of the regression line in the old age-group was less (p less than 0.05) than that in the young or middle age-group. Forearm vascular responses to the cold pressor test did not differ among the three age-groups. These results suggest that cardiac receptor control of forearm vascular resistance decreases with aging in humans.

UI	MeSH Term	Description	Entries
D008150	Lower Body Negative Pressure	External decompression applied to the lower body. It is used to study orthostatic intolerance and the effects of gravitation and acceleration, to produce simulated hemorrhage in physiologic research, to assess cardiovascular function, and to reduce abdominal stress during childbirth.	Abdominal Decompression,Decompression, Abdominal,LBNP
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011311	Pressoreceptors	Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.	Baroreceptors,Receptors, Stretch, Arterial,Receptors, Stretch, Vascular,Stretch Receptors, Arterial,Stretch Receptors, Vascular,Arterial Stretch Receptor,Arterial Stretch Receptors,Baroreceptor,Pressoreceptor,Receptor, Arterial Stretch,Receptor, Vascular Stretch,Receptors, Arterial Stretch,Receptors, Vascular Stretch,Stretch Receptor, Arterial,Stretch Receptor, Vascular,Vascular Stretch Receptor,Vascular Stretch Receptors
D002496	Central Venous Pressure	The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.	Venous Pressure, Central,Central Venous Pressures,Pressure, Central Venous,Pressures, Central Venous,Venous Pressures, Central
D005260	Female		Females
D005542	Forearm	Part of the upper extremity in humans and primates extending from the ELBOW to the WRIST.	Antebrachium,Antebrachiums,Forearms
D006321	Heart	The hollow, muscular organ that maintains the circulation of the blood.	Hearts
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults