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In a double-blind, randomized placebo controlled study, the effect of intracoronary (IC) nicardipine (0.4 mg) on methylergonovine (0.4 mg) induced coronary artery spasm was assessed in 16 patients with a history of variant angina. Reversal of the methylergonovine-induced coronary artery spasm was observed in 100% of patients treated with IC nicardipine and 25% of patients treated with placebo (p less than 0.01). There were no significant differences between the nicardipine and placebo treatment groups with respect to heart rate, blood pressure, proportion of patients experiencing chest pain or ST segment changes. These findings demonstrate that IC nicardipine is safe and could be effective in the reversal of coronary artery spasm in patients with variant angina.
M E Bertrand, and
J M La Blanche, and
P Hudon, and
S Grandy, and
P Turlapaty, and
A R Laddu
December 1986,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
M E Bertrand, and
J M La Blanche, and
P Hudon, and
S Grandy, and
P Turlapaty, and
A R Laddu
April 1991,
American heart journal,
M E Bertrand, and
J M La Blanche, and
P Hudon, and
S Grandy, and
P Turlapaty, and
A R Laddu
March 1979,
Circulation,
M E Bertrand, and
J M La Blanche, and
P Hudon, and
S Grandy, and
P Turlapaty, and
A R Laddu
February 1978,
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society,
M E Bertrand, and
J M La Blanche, and
P Hudon, and
S Grandy, and
P Turlapaty, and
A R Laddu
January 1980,
Indian heart journal: teaching series,
M E Bertrand, and
J M La Blanche, and
P Hudon, and
S Grandy, and
P Turlapaty, and
A R Laddu
January 1988,
The American journal of cardiology,
M E Bertrand, and
J M La Blanche, and
P Hudon, and
S Grandy, and
P Turlapaty, and
A R Laddu
February 1974,
British heart journal,
M E Bertrand, and
J M La Blanche, and
P Hudon, and
S Grandy, and
P Turlapaty, and
A R Laddu
March 1988,
Circulation,
M E Bertrand, and
J M La Blanche, and
P Hudon, and
S Grandy, and
P Turlapaty, and
A R Laddu
March 1991,
The New England journal of medicine,
M E Bertrand, and
J M La Blanche, and
P Hudon, and
S Grandy, and
P Turlapaty, and
A R Laddu
April 1985,
American heart journal,
