-transparent.png){kind=logo}
We investigated platelets and plasma from patients with idiopathic thrombocytopenic purpura (ITP) to elucidate the antigenic determinants at which their autoantibodies are directed, and studied the relationship between anti-platelet antibody and platelet volume. We used flow cytometry to detect platelet-associated IgG (PAIgG), C3 (PAC3), IgM (PAIgM) and platelet volume, and also to determine the binding rate of monoclonal anti-platelet antibodies in patients with ITP. The following results were obtained. 1. Both anti-GPIIb/IIIa autoantibodies (21 of 71 patients) and anti-GPIb autoantibodies (3 of 71 patients) were found in ITP. 2. The decrease in platelet count in patients without anti-GPIIb/IIIa autoantibodies was significant. 3. The increase in platelet volume was found more frequently in patients with a platelet count less than 50,000 and in untreated patients. 4. There was a positive correlation between the platelet volume and PAIgM in patients with a platelet count less than 30,000 and high levels of PAIgM.
S Nomura, and
T Soga, and
M Yanabu, and
M Suzuki, and
K Kondo, and
N Sone, and
C Kitada, and
H Nagata, and
T Kokawa, and
K Yasunaga
August 1991,
European journal of haematology,
S Nomura, and
T Soga, and
M Yanabu, and
M Suzuki, and
K Kondo, and
N Sone, and
C Kitada, and
H Nagata, and
T Kokawa, and
K Yasunaga
February 1997,
Blood,
S Nomura, and
T Soga, and
M Yanabu, and
M Suzuki, and
K Kondo, and
N Sone, and
C Kitada, and
H Nagata, and
T Kokawa, and
K Yasunaga
January 1994,
Haematologica,
S Nomura, and
T Soga, and
M Yanabu, and
M Suzuki, and
K Kondo, and
N Sone, and
C Kitada, and
H Nagata, and
T Kokawa, and
K Yasunaga
August 1972,
British journal of haematology,
S Nomura, and
T Soga, and
M Yanabu, and
M Suzuki, and
K Kondo, and
N Sone, and
C Kitada, and
H Nagata, and
T Kokawa, and
K Yasunaga
November 1988,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
S Nomura, and
T Soga, and
M Yanabu, and
M Suzuki, and
K Kondo, and
N Sone, and
C Kitada, and
H Nagata, and
T Kokawa, and
K Yasunaga
June 1989,
Hiroshima journal of medical sciences,
S Nomura, and
T Soga, and
M Yanabu, and
M Suzuki, and
K Kondo, and
N Sone, and
C Kitada, and
H Nagata, and
T Kokawa, and
K Yasunaga
November 1985,
The Journal of pediatrics,
S Nomura, and
T Soga, and
M Yanabu, and
M Suzuki, and
K Kondo, and
N Sone, and
C Kitada, and
H Nagata, and
T Kokawa, and
K Yasunaga
October 1984,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
S Nomura, and
T Soga, and
M Yanabu, and
M Suzuki, and
K Kondo, and
N Sone, and
C Kitada, and
H Nagata, and
T Kokawa, and
K Yasunaga
February 1988,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
S Nomura, and
T Soga, and
M Yanabu, and
M Suzuki, and
K Kondo, and
N Sone, and
C Kitada, and
H Nagata, and
T Kokawa, and
K Yasunaga
June 1985,
The Journal of the Association of Physicians of India,
