BIOMAT Database Logo BIOMAT Database Logo

Cushing syndrome due to primary pigmented nodular adrenocortical disease: findings at CT and MR imaging. 1989

J L Doppman, and W D Travis, and L Nieman, and D L Miller, and G P Chrousos, and M T Gomez, and G B Cutler, and D L Loriaux, and J A Norton
Diagnostic Radiology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892.

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of Cushing syndrome in infants, children, and young adults. It is characterized by non-adrenocorticotropic hormone-dependent hypersecretion of cortisol by multiple, pigmented nodules of hyperplastic adrenocortical cells. With a single exception, adrenal glands have been described as normal with computed tomography (CT) in all previous series. Eight patients had Cushing syndrome due to surgically proved PPNAD. Four of the eight patients had stigmas of Carney complex (lentigines, calcified Sertoli cell tumors of the testes, and cardiac and soft-tissue myxomas). CT and/or magnetic resonance (MR) imaging demonstrated unilateral or bilateral nodularity in five of six patients examined. Macronodules (greater than 10 mm) were seen in the two oldest patients. As the clinical presentation of Cushing syndrome in this group of patients may be atypical (severe osteoporosis or short stature), the detection of multiple, small adrenocortical nodules with CT or MR imaging supports, or may even suggest, the diagnosis of PPNAD.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003480 Cushing Syndrome A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent. Cushing's Syndrome,Hypercortisolism,Syndrome, Cushing,Syndrome, Cushing's
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000303 Adrenal Cortex Diseases Pathological processes of the ADRENAL CORTEX. Adrenal Cortex Disease,Cortex Disease, Adrenal,Cortex Diseases, Adrenal,Disease, Adrenal Cortex,Diseases, Adrenal Cortex
D000311 Adrenal Glands A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS. Adrenal Gland,Gland, Adrenal,Glands, Adrenal

Related Publications

J L Doppman, and W D Travis, and L Nieman, and D L Miller, and G P Chrousos, and M T Gomez, and G B Cutler, and D L Loriaux, and J A Norton
CT findings of primary pigmented nodular adrenocortical disease: rare cause of ACTH-independent Cushing syndrome.
June 2010, AJR. American journal of roentgenology,
J L Doppman, and W D Travis, and L Nieman, and D L Miller, and G P Chrousos, and M T Gomez, and G B Cutler, and D L Loriaux, and J A Norton
A case of subclinical Cushing syndrome due to primary pigmented nodular adrenocortical disease associated with adrenocortical adenoma.
August 2011, Endocrine,
J L Doppman, and W D Travis, and L Nieman, and D L Miller, and G P Chrousos, and M T Gomez, and G B Cutler, and D L Loriaux, and J A Norton
Bilateral primary pigmented nodular adrenocortical disease. Rare cause of the Cushing syndrome.
May 1984, The American journal of surgical pathology,
J L Doppman, and W D Travis, and L Nieman, and D L Miller, and G P Chrousos, and M T Gomez, and G B Cutler, and D L Loriaux, and J A Norton
Cushing syndrome in a young woman due to primary pigmented nodular adrenal disease.
January 2010, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists,
J L Doppman, and W D Travis, and L Nieman, and D L Miller, and G P Chrousos, and M T Gomez, and G B Cutler, and D L Loriaux, and J A Norton
[A girl with Cushing's syndrome due to primary pigmented nodular adrenocortical disease].
October 2006, Nederlands tijdschrift voor geneeskunde,
J L Doppman, and W D Travis, and L Nieman, and D L Miller, and G P Chrousos, and M T Gomez, and G B Cutler, and D L Loriaux, and J A Norton
Autoimmune involvement in Cushing syndrome due to primary adrenocortical nodular dysplasia.
November 1989, European journal of pediatrics,
J L Doppman, and W D Travis, and L Nieman, and D L Miller, and G P Chrousos, and M T Gomez, and G B Cutler, and D L Loriaux, and J A Norton
Primary pigmented nodular adrenocortical disease and Cushing's syndrome.
November 2007, Arquivos brasileiros de endocrinologia e metabologia,
J L Doppman, and W D Travis, and L Nieman, and D L Miller, and G P Chrousos, and M T Gomez, and G B Cutler, and D L Loriaux, and J A Norton
Primary pigmented nodular adrenocortical disease.
October 2011, Journal of Indian Association of Pediatric Surgeons,
J L Doppman, and W D Travis, and L Nieman, and D L Miller, and G P Chrousos, and M T Gomez, and G B Cutler, and D L Loriaux, and J A Norton
Primary pigmented nodular adrenocortical disease.
January 2011, Endokrynologia Polska,
J L Doppman, and W D Travis, and L Nieman, and D L Miller, and G P Chrousos, and M T Gomez, and G B Cutler, and D L Loriaux, and J A Norton
Primary pigmented nodular adrenocortical disease.
February 2024, Pathology,
Copied contents to your clipboard!