-transparent.png){kind=logo}
Synthesis of novel hydrazone and azole functionalized pyrazolo[3,4-b]pyridine derivatives as promising anticancer agents. 2016
P Nagender, and
R Naresh Kumar, and
G Malla Reddy, and
D Krishna Swaroop, and
Y Poornachandra, and
C Ganesh Kumar, and
B Narsaiah
Fluoroorganic Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
A series of novel pyrazolo[3,4-b]pyridine based target compounds were synthesized starting from the key intermediate ethyl 2-(3-amino-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate 5 on reaction with hydrazine hydrate followed by reaction with different aldehydes, acid chlorides and isothiocyanates to form hydrazones 7, oxadiazoles 8, 1,2,4 triazoles 10 and thiadiazoles 11 respectively in high yield. All the final compounds were screened for anticancer activity against four human cancer cell lines. Among them, 1,2,4 triazole derivatives showed promising activity and compound 10d is identified as a lead molecule.
Related Publications
P Nagender, and
R Naresh Kumar, and
G Malla Reddy, and
D Krishna Swaroop, and
Y Poornachandra, and
C Ganesh Kumar, and
B Narsaiah
November 2013,
Bioorganic & medicinal chemistry letters,
P Nagender, and
R Naresh Kumar, and
G Malla Reddy, and
D Krishna Swaroop, and
Y Poornachandra, and
C Ganesh Kumar, and
B Narsaiah
August 2016,
Bioorganic chemistry,
P Nagender, and
R Naresh Kumar, and
G Malla Reddy, and
D Krishna Swaroop, and
Y Poornachandra, and
C Ganesh Kumar, and
B Narsaiah
November 2009,
European journal of medicinal chemistry,
P Nagender, and
R Naresh Kumar, and
G Malla Reddy, and
D Krishna Swaroop, and
Y Poornachandra, and
C Ganesh Kumar, and
B Narsaiah
September 2021,
Bioorganic & medicinal chemistry letters,
P Nagender, and
R Naresh Kumar, and
G Malla Reddy, and
D Krishna Swaroop, and
Y Poornachandra, and
C Ganesh Kumar, and
B Narsaiah
January 2016,
Biological & pharmaceutical bulletin,
P Nagender, and
R Naresh Kumar, and
G Malla Reddy, and
D Krishna Swaroop, and
Y Poornachandra, and
C Ganesh Kumar, and
B Narsaiah
January 2012,
Organic & biomolecular chemistry,
P Nagender, and
R Naresh Kumar, and
G Malla Reddy, and
D Krishna Swaroop, and
Y Poornachandra, and
C Ganesh Kumar, and
B Narsaiah
July 2017,
European journal of medicinal chemistry,
P Nagender, and
R Naresh Kumar, and
G Malla Reddy, and
D Krishna Swaroop, and
Y Poornachandra, and
C Ganesh Kumar, and
B Narsaiah
January 2023,
RSC medicinal chemistry,
P Nagender, and
R Naresh Kumar, and
G Malla Reddy, and
D Krishna Swaroop, and
Y Poornachandra, and
C Ganesh Kumar, and
B Narsaiah
August 2007,
Bioorganic & medicinal chemistry letters,
P Nagender, and
R Naresh Kumar, and
G Malla Reddy, and
D Krishna Swaroop, and
Y Poornachandra, and
C Ganesh Kumar, and
B Narsaiah
February 2014,
Bioorganic & medicinal chemistry letters,
