Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats. 2016

Nobuaki Egashira, and Hikari Iba, and Haruna Kuwano, and Rikako Kawanaka, and Masaki Nagao, and Hiroshi Moriyama, and Takuya Watanabe, and Kaori Kubota, and Shutaro Katsurabayashi, and Katsunori Iwasaki
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan; Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan. Electronic address: n-egashi@pharm.med.kyushu-u.ac.jp.

In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30-300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.

UI MeSH Term Description Entries
D010052 Ovariectomy The surgical removal of one or both ovaries. Castration, Female,Oophorectomy,Bilateral Ovariectomy,Bilateral Ovariectomies,Castrations, Female,Female Castration,Female Castrations,Oophorectomies,Ovariectomies,Ovariectomies, Bilateral,Ovariectomy, Bilateral
D003213 Conditioning, Psychological Simple form of learning involving the formation, strengthening, or weakening of an association between a stimulus and a response. Conditioning, Psychology,Psychological Conditioning,Social Learning Theory,Social Learning Theories,Theory, Social Learning
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004365 Drugs, Chinese Herbal Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China. Chinese Herbal Drugs,Plant Extracts, Chinese,Chinese Drugs, Plant,Chinese Plant Extracts,Extracts, Chinese Plant,Herbal Drugs, Chinese
D005239 Fear The affective response to an actual current external danger which subsides with the elimination of the threatening condition. Threat Cues,Threat Sensitivity,Cue, Threat,Fears,Sensitivity, Threat,Threat Cue,Threat Sensitivities
D005260 Female Females
D005442 Flumazenil A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses. Flumazepil,Anexate,Lanexat,Ro 15-1788,Romazicon,Ro 15 1788,Ro 151788
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001640 Bicuculline An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors. 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one
D012934 Social Isolation The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication. Isolation, Social,Social Exclusion,Exclusion, Social,Social Exclusions

Related Publications

Nobuaki Egashira, and Hikari Iba, and Haruna Kuwano, and Rikako Kawanaka, and Masaki Nagao, and Hiroshi Moriyama, and Takuya Watanabe, and Kaori Kubota, and Shutaro Katsurabayashi, and Katsunori Iwasaki
June 1993, The Japanese journal of psychiatry and neurology,
Nobuaki Egashira, and Hikari Iba, and Haruna Kuwano, and Rikako Kawanaka, and Masaki Nagao, and Hiroshi Moriyama, and Takuya Watanabe, and Kaori Kubota, and Shutaro Katsurabayashi, and Katsunori Iwasaki
January 1996, Psychopharmacology,
Nobuaki Egashira, and Hikari Iba, and Haruna Kuwano, and Rikako Kawanaka, and Masaki Nagao, and Hiroshi Moriyama, and Takuya Watanabe, and Kaori Kubota, and Shutaro Katsurabayashi, and Katsunori Iwasaki
October 2000, European journal of pharmacology,
Nobuaki Egashira, and Hikari Iba, and Haruna Kuwano, and Rikako Kawanaka, and Masaki Nagao, and Hiroshi Moriyama, and Takuya Watanabe, and Kaori Kubota, and Shutaro Katsurabayashi, and Katsunori Iwasaki
March 2013, Neuroscience letters,
Nobuaki Egashira, and Hikari Iba, and Haruna Kuwano, and Rikako Kawanaka, and Masaki Nagao, and Hiroshi Moriyama, and Takuya Watanabe, and Kaori Kubota, and Shutaro Katsurabayashi, and Katsunori Iwasaki
July 1999, European journal of pharmacology,
Nobuaki Egashira, and Hikari Iba, and Haruna Kuwano, and Rikako Kawanaka, and Masaki Nagao, and Hiroshi Moriyama, and Takuya Watanabe, and Kaori Kubota, and Shutaro Katsurabayashi, and Katsunori Iwasaki
April 1996, Pharmacology, biochemistry, and behavior,
Nobuaki Egashira, and Hikari Iba, and Haruna Kuwano, and Rikako Kawanaka, and Masaki Nagao, and Hiroshi Moriyama, and Takuya Watanabe, and Kaori Kubota, and Shutaro Katsurabayashi, and Katsunori Iwasaki
March 1999, Psychopharmacology,
Nobuaki Egashira, and Hikari Iba, and Haruna Kuwano, and Rikako Kawanaka, and Masaki Nagao, and Hiroshi Moriyama, and Takuya Watanabe, and Kaori Kubota, and Shutaro Katsurabayashi, and Katsunori Iwasaki
August 1996, Pharmacology, biochemistry, and behavior,
Nobuaki Egashira, and Hikari Iba, and Haruna Kuwano, and Rikako Kawanaka, and Masaki Nagao, and Hiroshi Moriyama, and Takuya Watanabe, and Kaori Kubota, and Shutaro Katsurabayashi, and Katsunori Iwasaki
December 2021, Pharmacology, biochemistry, and behavior,
Nobuaki Egashira, and Hikari Iba, and Haruna Kuwano, and Rikako Kawanaka, and Masaki Nagao, and Hiroshi Moriyama, and Takuya Watanabe, and Kaori Kubota, and Shutaro Katsurabayashi, and Katsunori Iwasaki
October 1996, Pharmacology, biochemistry, and behavior,
Copied contents to your clipboard!