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Synthesis and hypoglycemic activity of 9-O-(lipophilic group substituted) berberine derivatives. 2016
Shanshan Zhang, and
Xiaohong Wang, and
Weicheng Yin, and
Zhenbao Liu, and
Mi Zhou, and
Daipeng Xiao, and
Yanfei Liu, and
Dongming Peng
Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
A series of 9-O-(lipophilic group substituted) berberine derivatives were synthesized and evaluated for their cytotoxicity and hypoglycemic activity against HepG2 cells. All the results indicated that most of the synthesized compounds exhibited lower cytotoxicity and a certain degree of hypoglycemic activity. Especially the compounds 5g and 5h displayed dramatically increased hypoglycemic activity compared with berberine, and the cytotoxicity maintained or even lower than berberine, indicating that they are potential candidates for new anti-type 2 diabetes mellitus drugs.
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