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The effects of naftidrofuryl on postischemic neuronal damage and on local cerebral blood flow (LCBF) were examined in a rat model of forebrain ischemia (occlusion of carotid arteries and hypotension). Ischemia was induced for 10 min. LCBF was measured after 2 and 10 min of recirculation. A histological evaluation of cell loss in the hippocampal areas was performed 7 days after ischemia. Naftidrofuryl (10 mg/kg) was administered intraperitoneally 15 min before ischemia. The drug reduced the percentage of necrotic neurons in the CA1 and CA4 sector of the hippocampus, while the LCBF of these hippocampal sections was not significantly altered. Thus, naftidrofuryl is suggested to protect hippocampal neurons against ischemic damage mainly by a direct effect on brain parenchyma.
J Krieglstein, and
D Sauer, and
J Nuglisch, and
C Rossberg, and
T Beck, and
G W Bielenberg, and
H D Mennel
September 2012,
Brain research,
J Krieglstein, and
D Sauer, and
J Nuglisch, and
C Rossberg, and
T Beck, and
G W Bielenberg, and
H D Mennel
October 2008,
Journal of neurochemistry,
J Krieglstein, and
D Sauer, and
J Nuglisch, and
C Rossberg, and
T Beck, and
G W Bielenberg, and
H D Mennel
July 1991,
Journal of pharmaceutical sciences,
J Krieglstein, and
D Sauer, and
J Nuglisch, and
C Rossberg, and
T Beck, and
G W Bielenberg, and
H D Mennel
April 1998,
Proceedings of the National Academy of Sciences of the United States of America,
J Krieglstein, and
D Sauer, and
J Nuglisch, and
C Rossberg, and
T Beck, and
G W Bielenberg, and
H D Mennel
March 1990,
Brain research,
J Krieglstein, and
D Sauer, and
J Nuglisch, and
C Rossberg, and
T Beck, and
G W Bielenberg, and
H D Mennel
December 2023,
Brain research bulletin,
J Krieglstein, and
D Sauer, and
J Nuglisch, and
C Rossberg, and
T Beck, and
G W Bielenberg, and
H D Mennel
July 1993,
The Journal of surgical research,
J Krieglstein, and
D Sauer, and
J Nuglisch, and
C Rossberg, and
T Beck, and
G W Bielenberg, and
H D Mennel
December 1995,
European journal of pharmacology,
J Krieglstein, and
D Sauer, and
J Nuglisch, and
C Rossberg, and
T Beck, and
G W Bielenberg, and
H D Mennel
February 2011,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
J Krieglstein, and
D Sauer, and
J Nuglisch, and
C Rossberg, and
T Beck, and
G W Bielenberg, and
H D Mennel
February 2016,
Neuropharmacology,
