Theobroma cacao extract attenuates the development of Dermatophagoides farinae-induced atopic dermatitis-like symptoms in NC/Nga mice. 2017

Heerim Kang, and Chang Hyung Lee, and Jong Rhan Kim, and Jung Yeon Kwon, and Myoung-Jin Son, and Jong-Eun Kim, and Ki Won Lee
Major in Biomodulation, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Republic of Korea; Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Republic of Korea.

Cacao beans from Theobroma cacao are an abundant source of polyphenols, particularly flavonoids. Previous studies demonstrated that cacao flavanols decrease pro-inflammatory cytokines resulting in the alleviation of allergic symptoms. We sought to investigate the effects of cacao extract (CE) on Dermatophagoides farinae extract (DFE)-induced atopic dermatitis (AD)-like symptoms. CE attenuated DFE-induced AD-like symptoms as assessed by skin lesion analyses, dermatitis score, and skin thickness. Histopathological analysis revealed that CE suppressed DFE-induced immune cell infiltration into the skin. These observations occurred concomitantly with the downregulation of inflammatory markers including serum immunoglobulin (Ig) E, chemokine; thymus and activation-regulated chemokine and macrophage-derived chemokine as well as the skin-derived cytokines interleukin (IL)-4, IL-5, and interferon-γ. CE also significantly alleviated transepidermal water loss and increased skin hydration. These results suggest that CE, a natural phytochemical-rich food, has potential therapeutic efficacy for the treatment of AD.

UI MeSH Term Description Entries
D007073 Immunoglobulin E An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). IgE
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D008297 Male Males
D008407 Mast Cells Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR. Basophils, Tissue,Basophil, Tissue,Cell, Mast,Cells, Mast,Mast Cell,Tissue Basophil,Tissue Basophils
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D002099 Cacao A tree of the family MALVACEAE, order MALVALES, whose seeds are processed to yield cocoa and CHOCOLATE. Cocoa Plant,Theobroma,Theobroma cacao,Plant, Cocoa
D003876 Dermatitis, Atopic A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema. Eczema, Atopic,Eczema, Infantile,Neurodermatitis, Atopic,Neurodermatitis, Disseminated,Atopic Dermatitis,Atopic Eczema,Atopic Neurodermatitis,Disseminated Neurodermatitis,Infantile Eczema
D004804 Eosinophils Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin. Eosinophil

Related Publications

Heerim Kang, and Chang Hyung Lee, and Jong Rhan Kim, and Jung Yeon Kwon, and Myoung-Jin Son, and Jong-Eun Kim, and Ki Won Lee
April 2022, Food & function,
Heerim Kang, and Chang Hyung Lee, and Jong Rhan Kim, and Jung Yeon Kwon, and Myoung-Jin Son, and Jong-Eun Kim, and Ki Won Lee
August 2017, The Journal of investigative dermatology,
Heerim Kang, and Chang Hyung Lee, and Jong Rhan Kim, and Jung Yeon Kwon, and Myoung-Jin Son, and Jong-Eun Kim, and Ki Won Lee
April 2015, Pharmaceutical biology,
Heerim Kang, and Chang Hyung Lee, and Jong Rhan Kim, and Jung Yeon Kwon, and Myoung-Jin Son, and Jong-Eun Kim, and Ki Won Lee
December 2016, Asian Pacific journal of allergy and immunology,
Heerim Kang, and Chang Hyung Lee, and Jong Rhan Kim, and Jung Yeon Kwon, and Myoung-Jin Son, and Jong-Eun Kim, and Ki Won Lee
June 2007, Allergology international : official journal of the Japanese Society of Allergology,
Heerim Kang, and Chang Hyung Lee, and Jong Rhan Kim, and Jung Yeon Kwon, and Myoung-Jin Son, and Jong-Eun Kim, and Ki Won Lee
March 2014, BMC complementary and alternative medicine,
Heerim Kang, and Chang Hyung Lee, and Jong Rhan Kim, and Jung Yeon Kwon, and Myoung-Jin Son, and Jong-Eun Kim, and Ki Won Lee
August 2015, Anticancer research,
Heerim Kang, and Chang Hyung Lee, and Jong Rhan Kim, and Jung Yeon Kwon, and Myoung-Jin Son, and Jong-Eun Kim, and Ki Won Lee
April 2017, Biochemical and biophysical research communications,
Heerim Kang, and Chang Hyung Lee, and Jong Rhan Kim, and Jung Yeon Kwon, and Myoung-Jin Son, and Jong-Eun Kim, and Ki Won Lee
November 2015, The Journal of investigative dermatology,
Heerim Kang, and Chang Hyung Lee, and Jong Rhan Kim, and Jung Yeon Kwon, and Myoung-Jin Son, and Jong-Eun Kim, and Ki Won Lee
January 2013, Evidence-based complementary and alternative medicine : eCAM,
Copied contents to your clipboard!