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Circulating human polymorphonuclear neutrophils are involved in asthma after their migration into the lung by local chemotactic factors. Investigation of the locomotion of neutrophils in Boyden chambers, showed that the chemotactic intensity of the platelet-activating factor (PAF) was similar in cells from healthy subjects and allergic asthmatics, although the optimal effect of the mediator was observed at 10(-6) M and 10(-8) M, respectively. Histamine had no direct chemoattractant effect on neutrophils but inhibited PAF-induced chemotaxis of neutrophils from healthy subjects and allergic asthmatics. This study provides additional evidence that neutrophils are involved in asthma, and points out the interaction between PAF and histamine in the migration of neutrophils to the lung.
M Rabier, and
M Damon, and
P Chanez, and
J M Mencia-Huerta, and
P Braquet, and
J Bousquet, and
F B Michel, and
P Godard
February 1991,
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M Rabier, and
M Damon, and
P Chanez, and
J M Mencia-Huerta, and
P Braquet, and
J Bousquet, and
F B Michel, and
P Godard
November 1990,
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M Rabier, and
M Damon, and
P Chanez, and
J M Mencia-Huerta, and
P Braquet, and
J Bousquet, and
F B Michel, and
P Godard
January 1992,
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M Rabier, and
M Damon, and
P Chanez, and
J M Mencia-Huerta, and
P Braquet, and
J Bousquet, and
F B Michel, and
P Godard
January 1991,
Medicina clinica,
M Rabier, and
M Damon, and
P Chanez, and
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P Braquet, and
J Bousquet, and
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P Godard
January 1980,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
M Rabier, and
M Damon, and
P Chanez, and
J M Mencia-Huerta, and
P Braquet, and
J Bousquet, and
F B Michel, and
P Godard
November 1988,
Hospital practice (Office ed.),
M Rabier, and
M Damon, and
P Chanez, and
J M Mencia-Huerta, and
P Braquet, and
J Bousquet, and
F B Michel, and
P Godard
April 1997,
Archivos de bronconeumologia,
M Rabier, and
M Damon, and
P Chanez, and
J M Mencia-Huerta, and
P Braquet, and
J Bousquet, and
F B Michel, and
P Godard
November 1993,
The Central African journal of medicine,
M Rabier, and
M Damon, and
P Chanez, and
J M Mencia-Huerta, and
P Braquet, and
J Bousquet, and
F B Michel, and
P Godard
January 1987,
International archives of allergy and applied immunology,
M Rabier, and
M Damon, and
P Chanez, and
J M Mencia-Huerta, and
P Braquet, and
J Bousquet, and
F B Michel, and
P Godard
April 1988,
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