This study was designed to examine the adaptive response of the human masseter muscle following surgical correction of abnormal facial form. Biopsies of the deep surface of the anterior superficial masseter muscle were obtained from five patients demonstrating vertical maxillary excess (VME), one at the time of corrective surgery, and a second at a long-term postoperative time interval (mean, 8 months). Control biopsies were also obtained from five individuals (three cadavers and two patients) with normal dentofacial morphology. A standard regimen of histologic and histochemical staining was used to classify individual muscle fibers as either type 1, type 2, or intermediate. In both VME patients and normal subjects type 1 fibers predominated, with the control group displaying a higher percentage (50% vs. 43%). On the average, type 1 fibers also had the largest areas. Following surgery there was an increase in type 2 fibers (30% vs. 52%). Two patients receiving maxillary surgery only exhibited either no change in mean fiber area or only a slight increase. The three remaining patients who underwent concomitant maxillary and mandibular surgery all showed a significant decrease in mean fiber area. Two persons in the latter group also showed features consistent with a denervation-reinnervation process. The results of this study indicate that the human masseter responds to surgical manipulation of the jaws in a histochemically demonstrable manner, with the nature and magnitude of the response associated with the particular surgical procedure(s) performed.