-transparent.png){kind=logo}
Polymethacrylic nanospheres (mean diameter 0.25-0.30 microns), prepared by aqueous emulsion copolymerization, were developed as a new site-specific drug delivery system. The nanoparticles were labeled either with indium-111 or iodine-125, and after a single iv injection of labeled particles into mice, their blood clearance and organ distribution were analyzed. A rapid clearance of 111In-labeled nanoparticles from the blood circulation to the mononuclear phagocyte system (MPS) was visualized using external scintigraphic imaging. From 10 to 60 min, radioactivity measurements in blood and organs (liver, spleen, kidneys, lungs, heart) showed that the 125I-labeled nanospheres were rapidly removed from the bloodstream (distribution half-life approximately 3-5 min) and mainly deposited in the liver (60% of the administered dose, 10 min after administration). Up to 1 h, radioactivity in heart and lungs remained insignificant, while in the kidneys, radioactivity levels increased from 8 to 11%.
A Rolland, and
B Collet, and
R Le Verge, and
L Toujas
March 2014,
Nanotoxicology,
A Rolland, and
B Collet, and
R Le Verge, and
L Toujas
January 2018,
Toxicology reports,
A Rolland, and
B Collet, and
R Le Verge, and
L Toujas
November 2012,
Nanotoxicology,
A Rolland, and
B Collet, and
R Le Verge, and
L Toujas
March 2010,
Archives of toxicology,
A Rolland, and
B Collet, and
R Le Verge, and
L Toujas
August 2011,
Toxicology letters,
A Rolland, and
B Collet, and
R Le Verge, and
L Toujas
April 1975,
The Journal of pharmacy and pharmacology,
A Rolland, and
B Collet, and
R Le Verge, and
L Toujas
January 1987,
Advances in experimental medicine and biology,
A Rolland, and
B Collet, and
R Le Verge, and
L Toujas
January 2013,
PloS one,
A Rolland, and
B Collet, and
R Le Verge, and
L Toujas
March 1990,
Antimicrobial agents and chemotherapy,
A Rolland, and
B Collet, and
R Le Verge, and
L Toujas
March 2008,
Archives of toxicology,
