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We have isolated and sequenced cDNA clones encoding the poly(A)-binding protein of Xenopus laevis oocytes. Polyclonal antiserum was raised against a fusion protein encoding 185 amino acids of the Xenopus poly(A)-binding protein. This antiserum localizes the poly(A)-binding protein to subcellular sites associated with protein synthesis; in the retina, immunoreactive protein is detected in the synthetically active inner segment of the photoreceptor but not in the transductive outer segment. Transcripts encoding the poly(A)-binding protein are present in oocytes, although no protein is detected on protein blots. In contrast, the levels of both transcripts and protein increase in development, which correlates with the observed increase in total poly(A) during Xenopus embryogenesis (N. Sagata, K. Shiokawa, and K. Yamana, Dev. Biol. 77:431-448, 1980).
B D Zelus, and
D H Giebelhaus, and
D W Eib, and
K A Kenner, and
R T Moon
December 1993,
The International journal of developmental biology,
B D Zelus, and
D H Giebelhaus, and
D W Eib, and
K A Kenner, and
R T Moon
September 2004,
Biology of the cell,
B D Zelus, and
D H Giebelhaus, and
D W Eib, and
K A Kenner, and
R T Moon
April 1987,
The Journal of cell biology,
B D Zelus, and
D H Giebelhaus, and
D W Eib, and
K A Kenner, and
R T Moon
October 2010,
Tissue & cell,
B D Zelus, and
D H Giebelhaus, and
D W Eib, and
K A Kenner, and
R T Moon
December 1991,
Proceedings of the National Academy of Sciences of the United States of America,
B D Zelus, and
D H Giebelhaus, and
D W Eib, and
K A Kenner, and
R T Moon
January 1991,
Biochemical and biophysical research communications,
B D Zelus, and
D H Giebelhaus, and
D W Eib, and
K A Kenner, and
R T Moon
September 2002,
Biology of the cell,
B D Zelus, and
D H Giebelhaus, and
D W Eib, and
K A Kenner, and
R T Moon
May 2003,
The International journal of developmental biology,
B D Zelus, and
D H Giebelhaus, and
D W Eib, and
K A Kenner, and
R T Moon
August 1988,
Developmental biology,
B D Zelus, and
D H Giebelhaus, and
D W Eib, and
K A Kenner, and
R T Moon
August 1990,
Nucleic acids research,
