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Experiments were carried out on 47 urethane-chloralose anesthetized and flaxedil immobilized rabbits under artificial respiration. Intracerebroventricular injection (ICV) of neostigmine (100 micrograms/200 microliters) caused a marked increase in blood pressure (BP), left ventricular pressure (LVP) and renal sympathetic nerve discharge (RND), while femoral blood flow (FBF) and conductance (COND), were decreased and the heart rate (HR) was initially reduced and then slightly increased. Microinjection of atropine (0.25 micrograms/site) into the rostral ventrolateral medulla (rVLM) caused a decrease in BP, HR, RND and LVP and a increase in FBF and COND. Pretreatment of atropine injection into rVLM before ICV of neostigmine blocked the pressor response of neostigmine. These results indicate that rVLM is important for the pressor response to ICV neostigmine, which may be mediated via cholinergic muscarinic receptors in rVLM.
Q G Xia, and
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P Li
April 1998,
Sheng li xue bao : [Acta physiologica Sinica],
Q G Xia, and
L Lu, and
P Li
September 1991,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
Q G Xia, and
L Lu, and
P Li
October 1994,
The American journal of physiology,
Q G Xia, and
L Lu, and
P Li
June 1993,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
Q G Xia, and
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October 2000,
Brain research bulletin,
Q G Xia, and
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P Li
September 2010,
Brain research,
Q G Xia, and
L Lu, and
P Li
March 2002,
Regulatory peptides,
Q G Xia, and
L Lu, and
P Li
February 1989,
The American journal of physiology,
Q G Xia, and
L Lu, and
P Li
December 1994,
Sheng li xue bao : [Acta physiologica Sinica],
Q G Xia, and
L Lu, and
P Li
June 1994,
The American journal of physiology,
