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The use of electrochemical iodination under potentiostatic conditions resulted in generating 131I-labeled alpha 2-interferon (IF) the antiviral activity of which differed statistically insignificantly from that of the intact preparation. The resulting radioactive analogue of alpha 2-IF was successfully used for the study of pharmacokinetics of reaferon (RFN) in experimental animals which determined the parameters of the processes of its elimination from the blood stream, accumulation and release from the liver, the organ in which the highest accumulation of alpha 2-IF is observed. It is concluded from the foregoing that it would be expedient to use RFN for treatment of viral disease of the liver and the lungs.
V N Kulakov, and
G N Pimenova, and
V A Matveev, and
G D Kobrinskiĭ, and
V P Kuznetsov
January 1989,
Voprosy virusologii,
V N Kulakov, and
G N Pimenova, and
V A Matveev, and
G D Kobrinskiĭ, and
V P Kuznetsov
June 1990,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
V N Kulakov, and
G N Pimenova, and
V A Matveev, and
G D Kobrinskiĭ, and
V P Kuznetsov
January 1990,
Terapevticheskii arkhiv,
V N Kulakov, and
G N Pimenova, and
V A Matveev, and
G D Kobrinskiĭ, and
V P Kuznetsov
January 1991,
Cancer chemotherapy and pharmacology,
V N Kulakov, and
G N Pimenova, and
V A Matveev, and
G D Kobrinskiĭ, and
V P Kuznetsov
July 1989,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
V N Kulakov, and
G N Pimenova, and
V A Matveev, and
G D Kobrinskiĭ, and
V P Kuznetsov
January 1988,
Voprosy virusologii,
V N Kulakov, and
G N Pimenova, and
V A Matveev, and
G D Kobrinskiĭ, and
V P Kuznetsov
February 1991,
Lancet (London, England),
V N Kulakov, and
G N Pimenova, and
V A Matveev, and
G D Kobrinskiĭ, and
V P Kuznetsov
February 1987,
Journal of interferon research,
V N Kulakov, and
G N Pimenova, and
V A Matveev, and
G D Kobrinskiĭ, and
V P Kuznetsov
September 1990,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
V N Kulakov, and
G N Pimenova, and
V A Matveev, and
G D Kobrinskiĭ, and
V P Kuznetsov
January 1989,
Voprosy virusologii,
