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A number of amphiphilic and lipid-soluble drugs of heterogeneous pharmacological properties, when injected into rat anterior tibial muscles, induced acute muscle fibre necrosis. The myotoxic agents were: penicillin, cloxacillin, phenobarbital, haloperidol, diazepam, hydantoin, metoclopramide, pentazocine and chlorpromazine. The regenerative process, studied using the latter three medications, showed rapid regeneration, complete within 3 weeks. Injection of the water-soluble drugs aminophylline, tranexamic acid and vitamins B6 and B12 produced no tissue damage. The pathogenesis of muscle fibre necrosis is suggested to involve direct damage to cell membranes by lipid soluble drugs.
D Manor, and
M Sadeh
January 1980,
The Medical journal of Australia,
D Manor, and
M Sadeh
June 1985,
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences,
D Manor, and
M Sadeh
September 1976,
The New England journal of medicine,
D Manor, and
M Sadeh
November 1976,
Ugeskrift for laeger,
D Manor, and
M Sadeh
August 2003,
Pain,
D Manor, and
M Sadeh
March 1985,
L' Infirmiere canadienne,
D Manor, and
M Sadeh
October 1982,
Muscle & nerve,
D Manor, and
M Sadeh
September 1985,
Anales espanoles de pediatria,
D Manor, and
M Sadeh
December 1989,
Forensic science international,
D Manor, and
M Sadeh
November 1968,
La Presse medicale,
