AMI remains a diagnostic and therapeutic challenge for the critical care nurse. As research and technology progress, a thorough understanding of the pathophysiology of AMI is necessary to appreciate and apply advances in the treatment of this condition. Likewise, if reductions in the morbidity and mortality of AMI are to be achieved, the nurse must be aware of potential complications, especially those related to ischemia, myocardial dysfunction, and dysrhythmia. Prompt diagnosis and treatment of the complications of AMI are the best approaches for minimizing fatalities, reducing hospital stays, and providing the best prognosis for patients with AMI.