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In the present study, isolated atrial function in spontaneously diabetic BB Wistar rats maintained for 12 weeks on a low (BB-LI) and a high (BB-HI) dosage of insulin was examined. Basal atrial rates were unchanged in the diabetic animals, relative to nondiabetic littermates (ND-BB) or Wistar controls. The BB-HI animals were euglycemic and responded to isoproterenol in a similar manner to the ND-BB and Wistar control animals. In contrast, BB-LI animals remained hyperglycemic and exhibited lower responses to the maximum chronotropic effects of isoproterenol. Plasma thyroid hormone levels were unaltered in the BB-diabetic animals. These results therefore reveal an absence of bradycardia and hypothyroidism in spontaneously diabetic BB rats, in contrast to previous observations in streptozotocin diabetic rats. However, a decrease in chronotropic response to isoproterenol was still noted in the BB-LI animals. These findings suggest that decreased positive chronotropic effect of isoproterenol in diabetes may not be a direct consequence of altered thyroid status.
S Ramanadham, and
G M McGrath, and
J H McNeill
January 1995,
Life sciences,
S Ramanadham, and
G M McGrath, and
J H McNeill
September 1989,
Diabetes,
S Ramanadham, and
G M McGrath, and
J H McNeill
October 1986,
Mechanisms of ageing and development,
S Ramanadham, and
G M McGrath, and
J H McNeill
July 1987,
Diabetes,
S Ramanadham, and
G M McGrath, and
J H McNeill
January 1982,
Acta biologica et medica Germanica,
S Ramanadham, and
G M McGrath, and
J H McNeill
September 1982,
Diabetologia,
S Ramanadham, and
G M McGrath, and
J H McNeill
January 1988,
Proceedings of the Western Pharmacology Society,
S Ramanadham, and
G M McGrath, and
J H McNeill
June 1989,
Canadian journal of physiology and pharmacology,
S Ramanadham, and
G M McGrath, and
J H McNeill
February 1991,
The Biochemical journal,
S Ramanadham, and
G M McGrath, and
J H McNeill
October 1993,
Acta ophthalmologica,
