Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats. 2016

Taj Pari Kalantaripour, and Saeed Esmaeili-Mahani, and Vahid Sheibani, and Majid Asadi-Shekaari, and Hamzeh Pasban-Aliabadi
Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.

Epilepsy is a common neurological disorder with no effective treatment or cure. Neuropeptide apelin is an endogenous ligand of angiotensin receptor-like 1 (APJ). It has been shown that apelin has protective and anti-neurodegenerative properties. This study was designed to evaluate the effect of apelin-13 on pentylenetetrazole (PTZ)-induced rat model of seizure. Adult male Wistar rats were divided into the experimental groups as follows: control group receiving PTZ; apelin-treated group which received apelin-13 before PTZ; apelin+F13A-treated group which received apelin-13 plus the apelin receptor antagonist (F13A) before PTZ; apelin+naloxone group which received apelin-13+naloxone before PTZ. Behavioral scoring was used to access seizure. The expression level of APJ was measured by western blotting. Neuronal degeneration, apoptosis and astrocyte activation were evaluated by vanadium acid fuchsin (VAF) staining and immunohistochemistry. Our data demonstrated that apelin-13 pretreatment significantly inhibited seizure threshold (p<0.001) and tonic-clonic latency (p<0.001) compared with the control group. In addition, PTZ-induced up-regulation of APJ was attenuated by apelin-13 treatment. Histological and immunohistochemical findings also showed that apelin-13 could protect cortical neurons against PTZ-induced neuroinflammation and apoptosis. In conclusion, apelin-13 has anticonvulsive and neuroprotective properties against PTZ-induced seizure in rats and provided a new pharmacological aspect of the neuropeptide apelin.

UI MeSH Term Description Entries
D008297 Male Males
D009410 Nerve Degeneration Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways. Neuron Degeneration,Degeneration, Nerve,Degeneration, Neuron,Degenerations, Nerve,Degenerations, Neuron,Nerve Degenerations,Neuron Degenerations
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D010433 Pentylenetetrazole A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility. Leptazole,Pentamethylenetetrazole,Pentetrazole,Cardiazol,Corasol,Corazol,Corazole,Korazol,Korazole,Metrazol,Metrazole,Pentazol,Pentylenetetrazol
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005904 Glial Fibrillary Acidic Protein An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000. Glial Intermediate Filament Protein,Astroprotein,GFA-Protein,Glial Fibrillary Acid Protein,GFA Protein
D000075244 Apelin Receptors G-protein coupled receptors for APELIN that function in a broad range of physiologic processes including blood pressure regulation and heart contractility. They also have an essential role in early embryo development for GASTRULATION and heart morphogenesis, and can also function as a CD4 co-receptor for HIV-1. APLNR,Angiotensin Receptor-Like 1 Protein,Apelin Receptor,Receptors, Apelin,Angiotensin Receptor Like 1 Protein,Receptor, Apelin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000927 Anticonvulsants Drugs used to prevent SEIZURES or reduce their severity. Anticonvulsant,Anticonvulsant Drug,Anticonvulsive Agent,Anticonvulsive Drug,Antiepileptic,Antiepileptic Agent,Antiepileptic Agents,Antiepileptic Drug,Anticonvulsant Drugs,Anticonvulsive Agents,Anticonvulsive Drugs,Antiepileptic Drugs,Antiepileptics,Agent, Anticonvulsive,Agent, Antiepileptic,Agents, Anticonvulsive,Agents, Antiepileptic,Drug, Anticonvulsant,Drug, Anticonvulsive,Drug, Antiepileptic,Drugs, Anticonvulsant,Drugs, Anticonvulsive,Drugs, Antiepileptic

Related Publications

Taj Pari Kalantaripour, and Saeed Esmaeili-Mahani, and Vahid Sheibani, and Majid Asadi-Shekaari, and Hamzeh Pasban-Aliabadi
June 2012, Neurochemistry international,
Taj Pari Kalantaripour, and Saeed Esmaeili-Mahani, and Vahid Sheibani, and Majid Asadi-Shekaari, and Hamzeh Pasban-Aliabadi
March 2023, Annales pharmaceutiques francaises,
Taj Pari Kalantaripour, and Saeed Esmaeili-Mahani, and Vahid Sheibani, and Majid Asadi-Shekaari, and Hamzeh Pasban-Aliabadi
February 2022, Neurochemical research,
Taj Pari Kalantaripour, and Saeed Esmaeili-Mahani, and Vahid Sheibani, and Majid Asadi-Shekaari, and Hamzeh Pasban-Aliabadi
April 1999, Indian journal of experimental biology,
Taj Pari Kalantaripour, and Saeed Esmaeili-Mahani, and Vahid Sheibani, and Majid Asadi-Shekaari, and Hamzeh Pasban-Aliabadi
July 2021, Journal of ethnopharmacology,
Taj Pari Kalantaripour, and Saeed Esmaeili-Mahani, and Vahid Sheibani, and Majid Asadi-Shekaari, and Hamzeh Pasban-Aliabadi
May 2020, Neurochemical research,
Taj Pari Kalantaripour, and Saeed Esmaeili-Mahani, and Vahid Sheibani, and Majid Asadi-Shekaari, and Hamzeh Pasban-Aliabadi
January 2021, Journal of ethnopharmacology,
Taj Pari Kalantaripour, and Saeed Esmaeili-Mahani, and Vahid Sheibani, and Majid Asadi-Shekaari, and Hamzeh Pasban-Aliabadi
June 2007, Peptides,
Taj Pari Kalantaripour, and Saeed Esmaeili-Mahani, and Vahid Sheibani, and Majid Asadi-Shekaari, and Hamzeh Pasban-Aliabadi
February 2021, Experimental brain research,
Taj Pari Kalantaripour, and Saeed Esmaeili-Mahani, and Vahid Sheibani, and Majid Asadi-Shekaari, and Hamzeh Pasban-Aliabadi
March 2023, Journal of basic and clinical physiology and pharmacology,
Copied contents to your clipboard!