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In this report, the maternal and fetal risks in a patient with paroxysmal nocturnal hemoglobinuria (PNH) were evaluated. A patient with PNH carried a pregnancy to successful delivery, with a healthy male infant, and suffered from postpartum cerebral subcortical, but not hepatic, thrombosis followed by recovery. An elevation of serum levels of lactate dehydrogenase isoenzyme, alpha-hydroxybutyrate dehydrogenase, was observed during pregnancy. The level was ameliorated to the non-pregnant level by delivery. However, hemoglobin concentrations during pregnancy and post-partum were at least 8 g/dl. This is a first report that shows tight coupling between an onset of intravenous hemolysis and pregnancy. The management of pregnancies in such patients is also discussed.
H Takagi, and
A Imai, and
I Kawabata, and
H Sumi, and
S Shiraki, and
T Tamaya
January 1976,
Obstetrics and gynecology,
H Takagi, and
A Imai, and
I Kawabata, and
H Sumi, and
S Shiraki, and
T Tamaya
December 2003,
Acta obstetricia et gynecologica Scandinavica,
H Takagi, and
A Imai, and
I Kawabata, and
H Sumi, and
S Shiraki, and
T Tamaya
October 1998,
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H Takagi, and
A Imai, and
I Kawabata, and
H Sumi, and
S Shiraki, and
T Tamaya
December 1982,
Obstetrics and gynecology,
H Takagi, and
A Imai, and
I Kawabata, and
H Sumi, and
S Shiraki, and
T Tamaya
March 1988,
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H Takagi, and
A Imai, and
I Kawabata, and
H Sumi, and
S Shiraki, and
T Tamaya
March 1994,
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H Takagi, and
A Imai, and
I Kawabata, and
H Sumi, and
S Shiraki, and
T Tamaya
January 2020,
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H Takagi, and
A Imai, and
I Kawabata, and
H Sumi, and
S Shiraki, and
T Tamaya
August 2002,
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H Takagi, and
A Imai, and
I Kawabata, and
H Sumi, and
S Shiraki, and
T Tamaya
December 2005,
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H Takagi, and
A Imai, and
I Kawabata, and
H Sumi, and
S Shiraki, and
T Tamaya
November 1991,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
