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Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest. 2016

David R Busch, and Craig G Rusin, and Wanda Miller-Hance, and Kathy Kibler, and Wesley B Baker, and Jeffrey S Heinle, and Charles D Fraser, and Arjun G Yodh, and Daniel J Licht, and Kenneth M Brady
Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.

While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement. Looking forward, DCS instrumentation, alone and with NIRS, could provide access to flow and metabolic biomarkers needed by clinicians to adjust neuroprotective therapy during surgery.

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