-transparent.png){kind=logo}
The hydroxylation of bile acids in rat liver microsomes in cyt P-450 dependent (Björkhem et al., 1975). To find out possible interactions between drugs and bile acid hydroxylation and/or active transport mechanisms we investigated the influence of the microsomal inhibitor metyrapon, the microsomal inducer phenobarbital and the intrahepatic cholestasis producing agents chlorpromazine, phenylbutazone and progesteron on bile flow and bile acid excretion. The excretion in monohydroxy (MBA), dihydroxy (DBA) and trihydroxy (TBA) bile acids were estimated in bile-fistula rats in three one hour periods. MBA, DBA and TBA were separated with thinlayer-chromatography and estimated fluorimetrically. Bile flow, bile acid excretion and relation TBA/DBA were influenced by acute and subchronic administration of the above mentioned drugs in different ways.
A Barth, and
R Bergmann, and
J Zaumseil, and
W Klinger
March 1983,
Revista espanola de fisiologia,
A Barth, and
R Bergmann, and
J Zaumseil, and
W Klinger
May 1883,
British medical journal,
A Barth, and
R Bergmann, and
J Zaumseil, and
W Klinger
June 1883,
British medical journal,
A Barth, and
R Bergmann, and
J Zaumseil, and
W Klinger
January 1980,
Die Pharmazie,
A Barth, and
R Bergmann, and
J Zaumseil, and
W Klinger
January 1985,
Acta physiologica Hungarica,
A Barth, and
R Bergmann, and
J Zaumseil, and
W Klinger
April 1965,
Lancet (London, England),
A Barth, and
R Bergmann, and
J Zaumseil, and
W Klinger
March 1965,
Lancet (London, England),
A Barth, and
R Bergmann, and
J Zaumseil, and
W Klinger
January 1967,
Clinical pharmacology and therapeutics,
A Barth, and
R Bergmann, and
J Zaumseil, and
W Klinger
January 1988,
European journal of clinical nutrition,
A Barth, and
R Bergmann, and
J Zaumseil, and
W Klinger
July 1998,
The Journal of nutrition,
