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The most important marker chromosome in patients with CDL is small acrocentric chromosome which is due to the deletion one of the chromosome 22. Ph 1 can be found only in adult type of CDL. Dhe authors present their experiences in citogeneticaly examined children with CDL. The examinations were done in six patients in peripheral blood and bone marrow. Ph 1 was negative only in one case. In the other patients philadelphia chromosome was found in bone marrow and in the peripheral blood only when the illness go from bad to worse.
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